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fabH 3-oxoacyl-[acyl carrier protein] synthase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946003, updated on 4-Apr-2024

Summary

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Gene symbol
fabH
Gene description
3-oxoacyl-[acyl carrier protein] synthase 3
Primary source
ASAP:ABE-0003696
Locus tag
b1091
See related
ECOCYC:EG10277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1077
Summary
fabH is an essential gene. [More information is available at EcoGene: EG10277]. There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG10277].
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Genomic context

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Sequence:
NC_000913.3 (1148759..1149712)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L32 Neighboring gene putative phosphate acyltransferase Neighboring gene [acyl-carrier-protein] S-malonyltransferase Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors. Lv PC, et al. Bioorg Med Chem Lett, 2009 Dec 1. PMID 19836235
  2. Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Gajiwala KS, et al. FEBS Lett, 2009 Sep 3. PMID 19665020
  3. Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics. Li HQ, et al. Bioorg Med Chem, 2009 Sep 1. PMID 19664929
  4. Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics. Lee JY, et al. Bioorg Med Chem, 2009 Feb 15. PMID 19185501
  5. Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Alhamadsheh MM, et al. Bioorg Med Chem Lett, 2008 Dec 15. PMID 18996691

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-ketoacyl-acyl-carrier-protein synthase III activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-ketoacyl-acyl-carrier-protein synthase III activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-oxoacyl-[acyl carrier protein] synthase 3
NP_415609.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1148759..1149712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415609.1 3-oxoacyl-[acyl carrier protein] synthase 3 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415609.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3Y4XVL2, A0A5B9B052
    Conserved Domains (1) summary
    PRK09352
    Location:1 → 317
    PRK09352; beta-ketoacyl-ACP synthase 3
Nucleotide Protein
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