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kdpA K(+) transporting P-type ATPase subunit KdpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946045, updated on 4-Apr-2024

Summary

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Gene symbol
kdpA
Gene description
K(+) transporting P-type ATPase subunit KdpA
Primary source
ASAP:ABE-0002381
Locus tag
b0698
See related
ECOCYC:EG10513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0686; kac
Summary
The kdpFABC genes encode an ATP-dependent high affinity P-Type ATPase potassium ion transporter . [More information is available at EcoCyc: EG10513].
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Genomic context

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Sequence:
NC_000913.3 (727059..728732, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase KdpD Neighboring gene K(+) transporting P-type ATPase subunit KdpC Neighboring gene K(+) transporting P-type ATPase subunit KdpB Neighboring gene K(+) transporting P-type ATPase subunit KdpF Neighboring gene DUF2517 domain-containing protein YbfA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The activity of the high-affinity K+ uptake system Kdp sensitizes cells of Escherichia coli to methylglyoxal. Ferguson GP, et al. J Bacteriol, 1996 Jul. PMID 8682804, Free PMC Article
  2. Sequence-directed DNA curvature in activator-binding sequence in the Escherichia coli kdp ABC promoter. Sugiura A, et al. Biosci Biotechnol Biochem, 1993 Feb. PMID 7763498
  3. Repressive control of potassium transport in Escherichia coli. Goldman D, et al. Biochim Biophys Acta, 1966 Dec 28. PMID 5339720
  4. Towards an understanding of the molecular mechanisms of stimulus perception and signal transduction by the KdpD/KdpE system of Escherichia coli. Jung K, et al. J Mol Microbiol Biotechnol, 2002 May. PMID 11931551
  5. Cs(+) induces the kdp operon of Escherichia coli by lowering the intracellular K(+) concentration. Jung K, et al. J Bacteriol, 2001 Jun. PMID 11371546, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for potassium transport in prokaryotes by KdpFABC.
    Title: Structural basis for potassium transport in prokaryotes by KdpFABC.
  2. Data indicate that KdpFABC P-type ATPase activity could be stimulated not only by the presence of the transported K+ ions in a pH-dependent manner but also, to a significantly lesser extent, by H+ and Na+.
    Title: Mechanistic analysis of the pump cycle of the KdpFABC P-type ATPase.
  3. Data show that the increase in the anionic lipid composition enhances the expression rate of the kdpFABC operon.
    Title: Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables P-type potassium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type potassium transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type potassium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of potassium ion-transporting ATPase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of potassium:proton antiporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
K(+) transporting P-type ATPase subunit KdpA
NP_415226.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    727059..728732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415226.1 K(+) transporting P-type ATPase subunit KdpA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415226.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA86ZVV1
    Conserved Domains (1) summary
    PRK05482
    Location:1 → 557
    PRK05482; potassium-transporting ATPase subunit A; Provisional
Nucleotide Protein
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