U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

gadC L-glutamate:4-aminobutyrate antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946057, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
gadC
Gene description
L-glutamate:4-aminobutyrate antiporter
Primary source
ASAP:ABE-0004973
Locus tag
b1492
See related
ECOCYC:G6786
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
acsA; ECK1486; xasA
Summary
EvgAS regulon. [More information is available at EcoGene: EG12456]. GadC, a glutamic acid:-aminobutyrate antiporter, is part of the glutamate-depenent acid resistance system 2 (AR2) which confers resistance to extreme acid conditions. [More information is available at EcoCyc: G6786].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1568954..1570489, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YddY Neighboring gene divisome localized glycosyl hydrolase Neighboring gene glutamate decarboxylase B Neighboring gene periplasmic metalloprotease

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria. Tsai MF, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530225, Free PMC Article
  2. The glutamate-dependent acid resistance system of Escherichia coli and Shigella flexneri is inhibited in vitro by L-trans-pyrrolidine-2,4-dicarboxylic acid. Waterman SR, et al. FEMS Microbiol Lett, 2003 Jul 15. PMID 12855178
  3. A glutamate-dependent acid resistance gene in Escherichia coli. Hersh BM, et al. J Bacteriol, 1996 Jul. PMID 8682809, Free PMC Article
  4. Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes. Castanie-Cornet MP, et al. Microbiology (Reading), 2001 Mar. PMID 11238978
  5. Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential. Richard H, et al. J Bacteriol, 2004 Sep. PMID 15342572, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular pH elevation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
L-glutamate:4-aminobutyrate antiporter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1568954..1570489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416009.1 L-glutamate:4-aminobutyrate antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416009.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A785ENL6, A0A8H9MQL1
    Conserved Domains (1) summary
    TIGR00910
    Location:8 → 509
    2A0307_GadC; glutamate:gamma-aminobutyrate antiporter
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.