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lsrF 3-hydroxy-2,4-pentadione 5-phosphate thiolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946071, updated on 2-May-2024

Summary

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Gene symbol
lsrF
Gene description
3-hydroxy-2,4-pentadione 5-phosphate thiolase
Primary source
ASAP:ABE-0005065
Locus tag
b1517
See related
ECOCYC:G6804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1510; yneB
Summary
LsrF is part of an operon for autoinducer-2 (AI-2) uptake regulated by LsrR and LuxS, through AI-2. [More information is available at EcoGene: EG13810].
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Genomic context

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Sequence:
NC_000913.3 (1606100..1606975)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD Neighboring gene Autoinducer-2 ABC transporter periplasmic binding protein Neighboring gene (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase Neighboring gene trans-aconitate 2-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Marques JC, et al. Proc Natl Acad Sci U S A, 2014 Sep 30. PMID 25225400, Free PMC Article
  2. The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. Diaz Z, et al. PLoS One, 2009 Aug 28. PMID 19714241, Free PMC Article
  3. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. Xavier KB, et al. ACS Chem Biol, 2007 Feb 20. PMID 17274596
  4. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2003 Nov. PMID 14622426
  5. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Taga ME, et al. Mol Microbiol, 2001 Nov. PMID 11722742

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-hydroxy-2,4-pentadione 5-phosphate thiolase
NP_416034.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1606100..1606975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416034.1 3-hydroxy-2,4-pentadione 5-phosphate thiolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416034.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9XL45
    Conserved Domains (1) summary
    PRK08227
    Location:28 → 291
    PRK08227; 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
Nucleotide Protein
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