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paaJ beta-ketoadipyl-CoA thiolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946121, updated on 4-Apr-2024

Summary

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Gene symbol
paaJ
Gene description
beta-ketoadipyl-CoA thiolase
Primary source
ASAP:ABE-0004668
Locus tag
b1397
See related
ECOCYC:G6718
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1394; ydbW
Summary
PaaJ is a -ketoadipyl-CoA thiolase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6718].
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Genomic context

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Sequence:
NC_000913.3 (1460893..1462098)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene phenylacetate-CoA ligase Neighboring gene DNA-binding transcriptional repressor PaaX Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the last step of the aerobic phenylacetic acid degradation pathway. Nogales J, et al. Microbiology (Reading), 2007 Feb. PMID 17259607
  2. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  3. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
  4. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
  5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-oxoadipyl-CoA thiolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoadipyl-CoA thiolase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA C-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3,4-dihydroxybenzoate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-ketoadipyl-CoA thiolase
NP_415915.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1460893..1462098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415915.1 beta-ketoadipyl-CoA thiolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415915.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6L7A056, W1X5A2
    Conserved Domains (1) summary
    PRK09050
    Location:1 → 401
    PRK09050; beta-ketoadipyl CoA thiolase; Validated
Nucleotide Protein
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