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mmuM homocysteine S-methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946143, updated on 2-May-2024

Summary

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Gene symbol
mmuM
Gene description
homocysteine S-methyltransferase
Primary source
ASAP:ABE-0000895
Locus tag
b0261
See related
ECOCYC:G6136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0263; yagD
Summary
Met regulon. [More information is available at EcoGene: EG13343]. MmuM is an S-methylmethionine: homocysteine methyltransferase involved in S-methylmethionine utilization . [More information is available at EcoCyc: G6136].
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Genomic context

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Sequence:
NC_000913.3 (276715..277647)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF00078 domain-containing protein YkfC Neighboring gene IS5 family transposase and trans-activator Neighboring gene S-methyl-L-methionine transporter Neighboring gene ABC transporter ATP-binding protein AfuC Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. Li K, et al. Biochem J, 2016 Feb 1. PMID 26564203
  2. Selenocysteine methyltransferase. Neuhierl B, et al. Methods Enzymol, 2002. PMID 11898408
  3. Cell division, one-carbon metabolism and methionine synthesis in a metK-deficient Escherichia coli mutant, and a role for MmuM. El-Hajj ZW, et al. Microbiology (Reading), 2013 Oct. PMID 23912937
  4. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
  5. Global analysis of candidate genes important for fitness in a competitive biofilm using DNA-array-based transposon mapping. Junker LM, et al. Microbiology (Reading), 2006 Aug. PMID 16849790

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structures of mmuM reveal a metal/substrate-binding pocket distinct from those in related enzymes.
    Title: Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
  2. The metK deficient Escherichia coli mutant uses externally provided S-adenosylmethionine as methyl donor to produce most but not all of its methionine, by methylation of homocysteine catalysed by MmuM.
    Title: Cell division, one-carbon metabolism and methionine synthesis in a metK-deficient Escherichia coli mutant, and a role for MmuM.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-methylmethionine-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in S-methylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within S-methylmethionine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homocysteine S-methyltransferase
NP_414795.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    276715..277647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414795.1 homocysteine S-methyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414795.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK09485
    Location:4 → 309
    mmuM; homocysteine methyltransferase; Provisional
Nucleotide Protein
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Gene LinkOut

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