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hdhA 7-alpha-hydroxysteroid dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946151, updated on 2-May-2024

Summary

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Gene symbol
hdhA
Gene description
7-alpha-hydroxysteroid dehydrogenase
Primary source
ASAP:ABE-0005419
Locus tag
b1619
See related
ECOCYC:EG10425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1614; hsd; hsdH
Summary
7--hydroxysteroid dehydrogenase catalyzes the dehydroxylation of cholic and chenodeoxycholic acids, major human bile acids, yielding 7-oxocholic and 7-oxochenodeoxycholic acids, respectively. [More information is available at EcoCyc: EG10425].
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Genomic context

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Sequence:
NC_000913.3 (1697273..1698040, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glucuronide:H(+) symporter Neighboring gene beta-glucuronidase Neighboring gene DNA-binding transcriptional repressor UidR Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene PTS enzyme IIBC component MalX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of the Ser146, Tyr159, and Lys163 residues in the catalytic action of 7alpha-hydroxysteroid dehydrogenase from Escherichia coli. Tanabe T, et al. J Biochem, 1998 Sep. PMID 9722677
  2. Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli. Tanaka N, et al. Biochemistry, 1996 Jun 18. PMID 8672472
  3. Location of the 7 alpha-hydroxysteroid dehydrogenase gene (hdhA) on the physical map of the Escherichia coli chromosome. Yoshimoto T, et al. J Bacteriol, 1993 Sep. PMID 8366061, Free PMC Article
  4. Cloning and sequencing of the 7 alpha-hydroxysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzyme. Yoshimoto T, et al. J Bacteriol, 1991 Apr. PMID 2007545, Free PMC Article
  5. Sequencing and high expression of aminopeptidase P gene from Escherichia coli HB101. Yoshimoto T, et al. J Biochem, 1989 Mar. PMID 2659585

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables cholate 7-alpha-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholate 7-alpha-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cholate 7-alpha-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bile acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
7-alpha-hydroxysteroid dehydrogenase
NP_416136.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1697273..1698040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416136.1 7-alpha-hydroxysteroid dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416136.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WUV7
    Conserved Domains (1) summary
    PRK06113
    Location:1 → 255
    PRK06113; 7-alpha-hydroxysteroid dehydrogenase; Validated
Nucleotide Protein
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