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murC UDP-N-acetylmuramate--L-alanine ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946153, updated on 2-May-2024

Summary

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Gene symbol
murC
Gene description
UDP-N-acetylmuramate--L-alanine ligase
Primary source
ASAP:ABE-0000324
Locus tag
b0091
See related
ECOCYC:EG10619
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0092
Summary
PDB: [More information is available at EcoGene: EG10619].
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Genomic context

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Sequence:
NC_000913.3 (100765..102240)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA Neighboring gene cell division protein FtsZ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway. Zawadzke LE, et al. Assay Drug Dev Technol, 2008 Feb. PMID 18315498
  2. Development of an LC-MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis. Deng G, et al. J Pharm Biomed Anal, 2004 Jun 29. PMID 15193726
  3. Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-l-alanine ligase. Ehmann DE, et al. Biochim Biophys Acta, 2004 May 6. PMID 15134649
  4. Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Deva T, et al. Acta Crystallogr D Biol Crystallogr, 2003 Aug. PMID 12876369
  5. Invariant amino acids in the Mur peptide synthetases of bacterial peptidoglycan synthesis and their modification by site-directed mutagenesis in the UDP-MurNAc:L-alanine ligase from Escherichia coli. Bouhss A, et al. Biochemistry, 1997 Sep 30. PMID 9305945

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramate:L-alanine ligase from Escherichia coli.
  2. The crystal structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC) has been determined to 2.6 A resolution.
    Title: Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylmuramate-L-alanine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylmuramate-L-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid-amino acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-N-acetylmuramate--L-alanine ligase
NP_414633.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    100765..102240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414633.1 UDP-N-acetylmuramate--L-alanine ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414633.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZGV2, A0A8T6PMU6
    Conserved Domains (1) summary
    PRK00421
    Location:13 → 484
    murC; UDP-N-acetylmuramate--L-alanine ligase; Provisional
Nucleotide Protein
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Gene LinkOut

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