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sufE sulfur carrier protein SufE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946173, updated on 25-Jan-2024

Summary

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Gene symbol
sufE
Gene description
sulfur carrier protein SufE
Primary source
ASAP:ABE-0005608
Locus tag
b1679
See related
ECOCYC:G6905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1675; ynhA
Summary
SufE is homologous to CsdE, encoded by the gene downstream of csdA. [More information is available at EcoGene: EG13961]. SufE acts as a sulfur acceptor that interacts with and increases the activity of the SufS cysteine desulfurase . [More information is available at EcoCyc: G6905].
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Genomic context

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Sequence:
NC_000913.3 (1758874..1759290, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein lipoprotein Neighboring gene L,D-transpeptidase LdtE Neighboring gene L-cysteine desulfurase Neighboring gene Fe-S cluster scaffold complex subunit SufD Neighboring gene Fe-S cluster scaffold complex subunit SufC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SufE sulfur-acceptor protein contains a conserved core structure that mediates interdomain interactions in a variety of redox protein complexes. Goldsmith-Fischman S, et al. J Mol Biol, 2004 Nov 19. PMID 15522304
  2. The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning. Gogar RK, et al. J Biol Chem, 2023 Mar. PMID 36736428, Free PMC Article
  3. SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase. Dai Y, et al. Biochemistry, 2015 Aug 11. PMID 26171726, Free PMC Article
  4. Mechanistic studies of the SufS-SufE cysteine desulfurase: evidence for sulfur transfer from SufS to SufE. Ollagnier-de-Choudens S, et al. FEBS Lett, 2003 Dec 4. PMID 14644425
  5. High-quality homology models derived from NMR and X-ray structures of E. coli proteins YgdK and Suf E suggest that all members of the YgdK/Suf E protein family are enhancers of cysteine desulfurases. Liu G, et al. Protein Sci, 2005 Jun. PMID 15930006, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The beta-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning.
    Title: The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning.
  2. These results show that dynamic changes may shift SufE to a sulfur-acceptor state that interacts more strongly with SufS.
    Title: SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase.
  3. Studies identified SufE-SufS and SufE-SufB interactions.
    Title: An in vivo method for characterization of protein interactions within sulfur trafficking systems of E. coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfur carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in metallo-sulfur cluster assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of sulfurtransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
sulfur carrier protein SufE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1758874..1759290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416194.1 sulfur carrier protein SufE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416194.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9B124
    Conserved Domains (1) summary
    PRK09296
    Location:1 → 126
    PRK09296; cysteine desulfuration protein SufE
Nucleotide Protein
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