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lpxL lauroyl acyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946216, updated on 6-Oct-2023

Summary

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Gene symbol
lpxL
Gene description
lauroyl acyltransferase
Primary source
ASAP:ABE-0003574
Locus tag
b1054
See related
ECOCYC:EG10464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1039; htrB; waaM
Summary
Lauroyl acyltransferase incorporates a laurate residue into KDO2-lipid IVA from lauroyl-ACP . [More information is available at EcoCyc: EG10464].
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Genomic context

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Sequence:
NC_000913.3 (1115662..1116582, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acidic protein MsyB Neighboring gene efflux pump MdtG Neighboring gene tRNA U34 hydroxylase TrhO Neighboring gene protein YceI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33 degrees C in rich media. Karow M, et al. J Bacteriol, 1991 Jan. PMID 1846149, Free PMC Article
  2. tRNA2Thr complements temperature sensitivity caused by null mutations in the htrB gene in Escherichia coli. Mohri Y, et al. J Bacteriol, 2003 Mar. PMID 12591892, Free PMC Article
  3. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Reynolds CM, et al. Biochemistry, 2009 Oct 13. PMID 19754149, Free PMC Article
  4. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. Vorachek-Warren MK, et al. J Biol Chem, 2002 Apr 19. PMID 11830595
  5. Effect of cold shock on lipid A biosynthesis in Escherichia coli. Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. Carty SM, et al. J Biol Chem, 1999 Apr 2. PMID 10092655

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lauroyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Kdo2-lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lauroyl acyltransferase
NP_415572.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1115662..1116582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415572.1 lauroyl acyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415572.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MV30, A0A7D7K9Y8
    Conserved Domains (1) summary
    PRK06860
    Location:1 → 306
    PRK06860; lipid A biosynthesis lauroyl acyltransferase; Provisional
Nucleotide Protein
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