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tsx nucleoside-specific channel-forming protein Tsx [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946242, updated on 2-May-2024

Summary

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Gene symbol
tsx
Gene description
nucleoside-specific channel-forming protein Tsx
Primary source
ASAP:ABE-0001425
Locus tag
b0411
See related
ECOCYC:EG11035
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0405; nupA; T6rec
Summary
First 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG11035]. Tsx is a protein involved with the permeation of ribo- and deoxy-nucleosides, across the outer membrane of Escherichia coli. [More information is available at EcoCyc: EG11035].
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Genomic context

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Sequence:
NC_000913.3 (431129..432013, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Sec translocon accessory complex subunit SecF Neighboring gene HNH nuclease family protein YajD Neighboring gene putative lipoprotein YajI Neighboring gene NrdR transcriptional repressor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of the bacterial nucleoside transporter Tsx. Ye J, et al. EMBO J, 2004 Aug 18. PMID 15272310, Free PMC Article
  2. Identification of a segment of the Escherichia coli Tsx protein that functions as a bacteriophage receptor area. Schneider H, et al. J Bacteriol, 1993 May. PMID 8491700, Free PMC Article
  3. Single amino acid substitutions affecting the substrate specificity of the Escherichia coli K-12 nucleoside-specific Tsx channel. Fsihi H, et al. J Biol Chem, 1993 Aug 15. PMID 8349629
  4. Stable albicidin resistance in Escherichia coli involves an altered outer-membrane nucleoside uptake system. Birch RG, et al. J Gen Microbiol, 1990 Jan. PMID 2191080
  5. Outer membrane of Escherichia coli K-12: TSX mutants (resistant to bacteriophage T6 and colicin K) lack an outer membrane protein. Manning PA, et al. Biochem Biophys Res Commun, 1976 Jul 26. PMID 786287

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides
    Title: Crystal structure of the bacterial nucleoside transporter Tsx.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside-specific channel forming porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within symbiont entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of pore complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoside-specific channel-forming protein Tsx

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    431129..432013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414945.1 nucleoside-specific channel-forming protein Tsx [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414945.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6PV85, A0A5B9AL25, A0A6L7CJP7
    Conserved Domains (1) summary
    PRK15106
    Location:1 → 294
    PRK15106; nucleoside-specific channel-forming protein Tsx; Provisional
Nucleotide Protein
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