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nupG nucleoside:H(+) symporter NupG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946282, updated on 11-Apr-2024

Summary

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Gene symbol
nupG
Gene description
nucleoside:H(+) symporter NupG
Primary source
ASAP:ABE-0009728
Locus tag
b2964
See related
ECOCYC:EG10664
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2959; gru
Summary
NupG, XapB and YegT are paralogs. [More information is available at EcoGene: EG10664]. NupG is one of two high-affinity nucleoside transporters in Escherichia coli. [More information is available at EcoCyc: EG10664].
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Genomic context

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Sequence:
NC_000913.3 (3105714..3106970)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative Fe(2(+))-trafficking protein Neighboring gene membrane-bound lytic murein transglycosylase C Neighboring gene constitutive ornithine decarboxylase Neighboring gene protein YqgH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG. Wang C, et al. J Biol Chem, 2021 Jan-Jun. PMID 33640454, Free PMC Article
  2. Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family. Xie H, et al. Mol Membr Biol, 2004 Sep-Oct. PMID 15513740
  3. Effect of exercise on the creatine resonances in 1H MR spectra of human skeletal muscle. Kreis R, et al. J Magn Reson, 1999 Apr. PMID 10089169
  4. Studies on the sequence and structure of the Escherichia coli K-12 nupG gene, encoding a nucleoside-transport system. Westh Hansen SE, et al. Eur J Biochem, 1987 Oct 15. PMID 3311747
  5. Gene-regulatory modules in Escherichia coli: nucleoprotein complexes formed by cAMP-CRP and CytR at the nupG promoter. Pedersen H, et al. Mol Microbiol, 1995 Sep. PMID 8596434

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG.
    Title: Molecular basis for substrate recognition by the bacterial nucleoside transporter NupG.
  2. Oligohistidine-tagged form of NupG from Escherichia coli was purified and characterized.
    Title: Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cytidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside:proton symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine nucleoside transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adenosine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytidine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within purine nucleoside transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pyrimidine nucleoside transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine-containing compound transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uridine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
nucleoside:H(+) symporter NupG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3105714..3106970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417439.4 nucleoside:H(+) symporter NupG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417439.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7H9QTJ8
    Conserved Domains (1) summary
    TIGR00889
    Location:1 → 418
    2A0110; nucleoside transporter
Nucleotide Protein
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