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PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

Gene ID: 9463, updated on 4-Jan-2025

Summary

Official Symbol
PICK1provided by HGNC
Official Full Name
protein interacting with PRKCA 1provided by HGNC
Primary source
HGNC:HGNC:9394
See related
Ensembl:ENSG00000100151 MIM:605926; AllianceGenome:HGNC:9394
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PICK; PRKCABP
Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See PICK1 in Genome Data Viewer
Location:
22q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38057255..38075701)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38518878..38537327)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene MPRA-validated peak4487 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38378831-38379668 Neighboring gene VISTA enhancer hs564 Neighboring gene SRY-box transcription factor 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38392633-38393194 Neighboring gene VISTA enhancer hs486 Neighboring gene microRNA 4534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38424434-38424934 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:38427029-38428228 Neighboring gene VISTA enhancer hs491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38438297-38438796 Neighboring gene VISTA enhancer hs492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446442-38446942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38446943-38447443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38452863-38453488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38453489-38454112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38470967-38471468 Neighboring gene uncharacterized LOC105373027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38476553-38477334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38479675-38480456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC15204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding  
enables G protein-coupled receptor binding  
enables actin filament binding  
enables identical protein binding PubMed 
enables identical protein binding  
enables membrane curvature sensor activity PubMed 
enables metal ion binding  
enables phospholipid binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein kinase C binding  
enables protein kinase C binding  
enables signaling receptor binding  
Process Evidence Code Pubs
involved_in cellular response to decreased oxygen levels  
involved_in cellular response to glucose starvation  
involved_in dendritic spine maintenance  
involved_in dendritic spine maintenance  
involved_in dendritic spine organization  
involved_in glial cell development  
involved_in intracellular protein transport  
involved_in long-term synaptic depression  
involved_in monoamine transport PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation  
involved_in neuronal ion channel clustering PubMed 
involved_in positive regulation of receptor internalization  
involved_in positive regulation of receptor internalization  
involved_in protein phosphorylation  
involved_in receptor clustering  
involved_in receptor clustering  
involved_in regulation of Arp2/3 complex-mediated actin nucleation  
involved_in regulation of insulin secretion PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in cytoplasm PubMed 
located_in cytoskeleton  
located_in cytosol  
located_in endocytic vesicle membrane  
is_active_in neuron projection  
located_in neuron projection  
located_in perinuclear region of cytoplasm  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in postsynaptic density  
is_active_in postsynaptic early endosome  
located_in presynaptic membrane PubMed 
located_in synapse  
is_active_in synaptic vesicle  
is_active_in trans-Golgi network membrane  

General protein information

Preferred Names
PRKCA-binding protein
Names
protein interacting with C kinase 1
protein kinase C-alpha-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039583.1NP_001034672.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561, CN482899
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENSP00000385205.3, ENST00000404072.7
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  2. NM_001039584.1NP_001034673.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENST00000484021.5
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  3. NM_012407.4NP_036539.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_036539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    B3KS52, O95906, Q9NRD5
    UniProtKB/TrEMBL
    B3KM22
    Related
    ENSP00000349465.3, ENST00000356976.8
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38057255..38075701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441609.1XP_047297565.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
  2. XM_047441610.1XP_047297566.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
  3. XM_011530517.4XP_011528819.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
    Conserved Domains (2) summary
    cd07659
    Location:147342
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  4. XM_047441611.1XP_047297567.1  PRKCA-binding protein isoform X2

  5. XM_047441613.1XP_047297569.1  PRKCA-binding protein isoform X4

  6. XM_047441612.1XP_047297568.1  PRKCA-binding protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38518878..38537327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326142.1XP_054182117.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
  2. XM_054326143.1XP_054182118.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
  3. XM_054326141.1XP_054182116.1  PRKCA-binding protein isoform X1

    UniProtKB/TrEMBL
    B3KM22
  4. XM_054326144.1XP_054182119.1  PRKCA-binding protein isoform X2

  5. XM_054326146.1XP_054182121.1  PRKCA-binding protein isoform X4

  6. XM_054326145.1XP_054182120.1  PRKCA-binding protein isoform X3

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