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ldhA D-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946315, updated on 11-Apr-2024

Summary

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Gene symbol
ldhA
Gene description
D-lactate dehydrogenase
Primary source
ASAP:ABE-0004619
Locus tag
b1380
See related
ECOCYC:G592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1377; hslF; hslI; htpH
Summary
There are three lactate dehydrogenase enzymes in Escherichia coli which interconvert pyruvate and lactate. [More information is available at EcoCyc: G592].
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Genomic context

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Sequence:
NC_000913.3 (1441854..1442843, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pyruvate-flavodoxin oxidoreductase Neighboring gene DUF333 domain-containing protein YdbJ Neighboring gene lipoprotein implicated in Novobiocin resistance Neighboring gene putative phospholipid transport factor YdbH Neighboring gene lipoprotein YnbE Neighboring gene DUF1318 domain-containing protein YdbL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation. Yamamoto N, et al. Microbiol Immunol, 2022 May. PMID 35174526
  2. Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation. Yamamoto N, et al. J Biosci Bioeng, 2018 Jul. PMID 29449156
  3. Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. Furukawa N, et al. AMB Express, 2014. PMID 25401076, Free PMC Article
  4. Functional replacement of the Escherichia coli D-(-)-lactate dehydrogenase gene (ldhA) with the L-(+)-lactate dehydrogenase gene (ldhL) from Pediococcus acidilactici. Zhou S, et al. Appl Environ Microbiol, 2003 Apr. PMID 12676706, Free PMC Article
  5. Reconstitution of D-lactate-dependent transport in membrane vesicles from a D-lactate dehydrogenase mutant of Escherichia coli. Reeves JP, et al. Proc Natl Acad Sci U S A, 1973 Jul. PMID 4579004, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation.
    Title: ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation.
  2. LdhA-mediated persister formation pathway is different from previously reported persister formation via repression of aerobic metabolism.
    Title: Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation.
  3. The gene encoding malate dehydrogenase (MDH) was overexpressed in a pflB ldhA double mutant, NZN111, for succinic acid production.
    Title: Production of succinate by a pflB ldhA double mutant of Escherichia coli overexpressing malate dehydrogenase.
  4. Deletion of the E. coli ldhA gene (together with deletions of other ferementation disruption genes) increased production of succinate
    Title: Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-lactate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mixed acid fermentation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mixed acid fermentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-lactate dehydrogenase
NP_415898.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1441854..1442843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415898.1 D-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415898.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377BGV6
    Conserved Domains (1) summary
    cd12183
    Location:1 → 328
    LDH_like_2; D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains
Nucleotide Protein
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