U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

murG N-acetylglucosaminyl transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946321, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
murG
Gene description
N-acetylglucosaminyl transferase
Primary source
ASAP:ABE-0000322
Locus tag
b0090
See related
ECOCYC:EG10623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0091
Summary
Essential gene, Mengin-Lecreulx(1991). [More information is available at EcoGene: EG10623]. The murG gene codes for the N-acetylglucosaminyl transferase responsible for the final intracellular step of peptidoglycan subunit assembly. [More information is available at EcoCyc: EG10623].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (99644..100711)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of the amino acid invariants in the active site of MurG as evaluated by site-directed mutagenesis. Crouvoisier M, et al. Biochimie, 2007 Dec. PMID 17692452
  2. Transmembrane transport of peptidoglycan precursors across model and bacterial membranes. van Dam V, et al. Mol Microbiol, 2007 May. PMID 17501931
  3. Scintillation proximity assay for inhibitors of Escherichia coli MurG and, optionally, MraY. Ravishankar S, et al. Antimicrob Agents Chemother, 2005 Apr. PMID 15793120, Free PMC Article
  4. Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening. Hu Y, et al. Chem Biol, 2004 May. PMID 15157881
  5. A fluorescent analogue of UDP-N-acetylglucosamine: application for FRET assay of peptidoglycan translocase II (MurG). Li JJ, et al. Chem Commun (Camb), 2004 Jan 21. PMID 14737539

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The murG gene of Escherichia coli codes for the UDP-N-acetylglucosamine: N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase involved in the membrane steps of peptidoglycan synthesis.
  2. It is postulated that the involvement of MurG in the peptidoglycan synthesis concurs with two complexes, one implicated in cell elongation and the other in division.
    Title: The essential peptidoglycan glycosyltransferase MurG forms a complex with proteins involved in lateral envelope growth as well as with proteins involved in cell division in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate derivative biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N-acetylglucosaminyl transferase
NP_414632.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    99644..100711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414632.1 N-acetylglucosaminyl transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414632.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3Z6G549, A0A6N2Y9H6
    Conserved Domains (1) summary
    PRK00726
    Location:6 → 355
    murG; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.