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manX mannose-specific PTS enzyme IIAB component [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946334, updated on 11-Apr-2024

Summary

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Gene symbol
manX
Gene description
mannose-specific PTS enzyme IIAB component
Primary source
ASAP:ABE-0006054
Locus tag
b1817
See related
ECOCYC:EG10567
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1815; gptB; mpt; ptsL; ptsX
Summary
HT_Cmplx16_Mem: [More information is available at EcoGene: EG10567]. This subunit contains PTS Enzyme IIA and IIB domains. [More information is available at EcoCyc: EG10567].
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Genomic context

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Sequence:
NC_000913.3 (1902048..1903019)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative c-di-GMP phosphodiesterase PdeD Neighboring gene TerC family inner membrane protein YoaE Neighboring gene protein YoaL Neighboring gene mannose-specific PTS enzyme IIC component Neighboring gene mannose-specific PTS enzyme IID component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 13C-detected HN(CA)C and HMCMC experiments using a single methyl-reprotonated sample for unambiguous methyl resonance assignment. Hu K, et al. J Biomol NMR, 2006 Dec. PMID 17036159
  2. Solution NMR structure of the 48-kDa IIAMannose-HPr complex of the Escherichia coli mannose phosphotransferase system. Williams DC Jr, et al. J Biol Chem, 2005 May 27. PMID 15788390, Free PMC Article
  3. Secondary structure of the IIB domain of the Escherichia coli mannose transporter, a new fold in the class of alpha/beta twisted open-sheet structures. Gschwind RM, et al. FEBS Lett, 1997 Mar 3. PMID 9074635
  4. Predicted topology of the N-terminal domain of the hydrophilic subunit of the mannose transporter of Escherichia coli. Marković-Housley Z, et al. FEBS Lett, 1994 Mar 7. PMID 8131846
  5. Mannose permease of Escherichia coli. Domain structure and function of the phosphorylating subunit. Erni B, et al. J Biol Chem, 1989 Nov 5. PMID 2681202

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis.
  2. solution structure of a stably phosphorylated form of the cytoplasmic B domain of (IIB(Mtl)) of the E coli phosphotransferase system, containing a mutation of the active site Cys384 to Ser, solved by NMR
    Title: Visualization of the phosphorylated active site loop of the cytoplasmic B domain of the mannitol transporter II(Mannitol) of the Escherichia coli phosphotransferase system by NMR spectroscopy and residual dipolar couplings.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mannose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mannose transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
mannose-specific PTS enzyme IIAB component
NP_416331.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1902048..1903019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416331.1 mannose-specific PTS enzyme IIAB component [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416331.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NE64, A0A8S7XW71
    Conserved Domains (1) summary
    PRK15088
    Location:1 → 321
    PRK15088; PTS system mannose-specific transporter subunits IIAB; Provisional
Nucleotide Protein
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