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eda KHG/KDPG aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946367, updated on 2-May-2024

Summary

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Gene symbol
eda
Gene description
KHG/KDPG aldolase
Primary source
ASAP:ABE-0006164
Locus tag
b1850
See related
ECOCYC:EG10256
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1851; hga; kdgA; kga
Summary
Eda: [More information is available at EcoCyc: EG10256].
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Genomic context

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Sequence:
NC_000913.3 (1932115..1932756, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA damage-inducible protein YebG Neighboring gene phosphoribosylglycinamide formyltransferase 2 Neighboring gene phosphogluconate dehydratase Neighboring gene NADP(+)-dependent glucose-6-phosphate dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates. Cheriyan M, et al. Protein Sci, 2007 Nov. PMID 17962400, Free PMC Article
  2. Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution. Allard J, et al. Proc Natl Acad Sci U S A, 2001 Mar 27. PMID 11274385, Free PMC Article
  3. Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of D- and L-sugars. Fong S, et al. Chem Biol, 2000 Nov. PMID 11094340
  4. Recovery of respiration following the SOS response of Escherichia coli requires RecA-mediated induction of 2-keto-4-hydroxyglutarate aldolase. Cayrol C, et al. Proc Natl Acad Sci U S A, 1995 Dec 5. PMID 8524853, Free PMC Article
  5. Steady-state kinetics and inhibition studies of the aldol condensation reaction catalyzed by bovine liver and Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Grady SR, et al. Biochemistry, 1981 Apr 28. PMID 7016177

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (4S)-4-hydroxy-2-oxoglutarate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-dehydro-3-deoxy-phosphogluconate aldolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 4-hydroxy-2-oxoglutarate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxy-2-oxoglutarate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxo-acid-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
KHG/KDPG aldolase
NP_416364.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1932115..1932756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416364.1 KHG/KDPG aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416364.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ALR2
    Conserved Domains (1) summary
    PRK05718
    Location:1 → 212
    PRK05718; keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional
Nucleotide Protein
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