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fecA ferric citrate outer membrane transporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946427, updated on 4-Apr-2024

Summary

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Gene symbol
fecA
Gene description
ferric citrate outer membrane transporter
Primary source
ASAP:ABE-0014067
Locus tag
b4291
See related
ECOCYC:EG10286
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4281
Summary
FecA is the TonB energy transducing system-dependent ferric citrate uptake receptor. [More information is available at EcoCyc: EG10286].
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Genomic context

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Sequence:
NC_000913.3 (4514353..4516677, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric citrate ABC transporter membrane subunit FecD Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate regulator FecR Neighboring gene RNA polymerase sigma factor FecI Neighboring gene protein YkiE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli. Lupino KM, et al. BMC Microbiol, 2018 Apr 18. PMID 29669516, Free PMC Article
  2. Conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA: a molecular dynamics simulation study. Piggot TJ, et al. Biochim Biophys Acta, 2013 Feb. PMID 22960041
  3. Predicting the complex structure and functional motions of the outer membrane transporter and signal transducer FecA. Sen TZ, et al. Biophys J, 2008 Apr 1. PMID 18178655, Free PMC Article
  4. Nuclear magnetic resonance solution structure of the periplasmic signalling domain of the TonB-dependent outer membrane transporter FecA from Escherichia coli. Garcia-Herrero A, et al. Mol Microbiol, 2005 Dec. PMID 16313612
  5. Bacterial metal detectors. Buchanan SK. Mol Microbiol, 2005 Dec. PMID 16313609, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. fecA gene plays a role in ethanol tolerance.
    Title: A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli.
  2. analysis of conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA
    Title: Conformational dynamics and membrane interactions of the E. coli outer membrane protein FecA: a molecular dynamics simulation study.
  3. High concentrations of stabilizing solutes, such as those used to generate membrane protein crystals, result in a more compact and ordered state of the protein than is seen under more physiological conditions.
    Title: Solutes alter the conformation of the ligand binding loops in outer membrane transporters.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Genetics of the iron dicitrate transport system of Escherichia coli.
  5. NMR solution structure presented of periplasmic signaling n-terminal domain including TonB box region
    Title: Nuclear magnetic resonance solution structure of the periplasmic signalling domain of the TonB-dependent outer membrane transporter FecA from Escherichia coli.
  6. Results indicate that FecA N-terminal domain interferes with TonB-CTD binding to the TonB box.
    Title: Characterization of TonB interactions with the FepA cork domain and FecA N-terminal signaling domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables siderophore-iron transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to iron ion starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siderophore transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore-dependent iron import into cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within siderophore-dependent iron import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction involved in regulation of gene expression TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ferric citrate outer membrane transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4514353..4516677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418711.1 ferric citrate outer membrane transporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418711.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87EPT4
    Conserved Domains (1) summary
    COG4772
    Location:51 → 774
    FecA; Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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