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ampG muropeptide:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946438, updated on 4-Feb-2024

Summary

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Gene symbol
ampG
Gene description
muropeptide:H(+) symporter
Primary source
ASAP:ABE-0001501
Locus tag
b0433
See related
ECOCYC:EG12183
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0427
Summary
Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. [More information is available at EcoGene: EG12183]. AmpG is a member of the major facilitator superfamily of transporters, and together with AmpD, is essential for induction of the AmpC -lactamase and is involved in the recycling of cell wall peptides . [More information is available at EcoCyc: EG12183].
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Genomic context

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Sequence:
NC_000913.3 (452070..453545, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bo3 subunit 3 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene cytochrome bo3 subunit 2 Neighboring gene putative lipoprotein YajG Neighboring gene DNA-binding transcriptional dual regulator BolA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of AmpG in mediating a dynamic relationship between serine beta-lactamase induction and biofilm-forming ability of Escherichia coli. Mallik D, et al. FEMS Microbiol Lett, 2018 Apr 1. PMID 29566229
  2. Induction of beta-lactamase in Enterobacter cloacae. Wiedemann B, et al. Clin Infect Dis, 1998 Aug. PMID 9710670
  3. beta-Lactamase induction in gram-negative bacteria is intimately linked to peptidoglycan recycling. Normark S. Microb Drug Resist, 1995 Summer. PMID 9158742
  4. AmpD, essential for both beta-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase. Jacobs C, et al. Mol Microbiol, 1995 Feb. PMID 7783625
  5. The signal transducer encoded by ampG is essential for induction of chromosomal AmpC beta-lactamase in Escherichia coli by beta-lactam antibiotics and 'unspecific' inducers. Schmidt H, et al. Microbiology (Reading), 1995 May. PMID 7773404

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of AmpG permease decrease in the biofilm-forming ability.
    Title: Involvement of AmpG in mediating a dynamic relationship between serine beta-lactamase induction and biofilm-forming ability of Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
muropeptide:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    452070..453545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414967.1 muropeptide:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414967.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A3C163
    Conserved Domains (1) summary
    PRK11010
    Location:1 → 490
    ampG; muropeptide MFS transporter AmpG
Nucleotide Protein
Heading Accession and Version

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