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thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946459, updated on 23-Nov-2023

Summary

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Gene symbol
thiD
Gene description
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
Primary source
ASAP:ABE-0006958
Locus tag
b2103
See related
ECOCYC:G7135
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2096; thiA; thiJ
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Genomic context

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Sequence:
NC_000913.3 (2183716..2184516, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sugar kinase YegV Neighboring gene putative DNA-binding transcriptional regulator YegW Neighboring gene putative glycosyl hydrolase YegX Neighboring gene hydroxyethylthiazole kinase Neighboring gene DNA-binding transcriptional repressor RcnR Neighboring gene Ni(2(+))/Co(2(+)) exporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. thiD locus of Escherichia coli. Imamura N, et al. Experientia, 1981 Dec 15. PMID 6276219
  2. An efficient enzymatic synthesis of thiamin pyrophosphate. Melnick JS, et al. Bioorg Med Chem Lett, 2003 Nov 17. PMID 14592524
  3. The thiJ locus and its relation to phosphorylation of hydroxymethylpyrimidine in Escherichia coli. Mizote T, et al. Microbiology (Reading), 1996 Oct. PMID 8885414
  4. The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite. Reddick JJ, et al. Bioorg Med Chem Lett, 2001 Sep 3. PMID 11527707
  5. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. Vander Horn PB, et al. J Bacteriol, 1993 Feb. PMID 8432721, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylpyrimidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylpyrimidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxymethylpyrimidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphomethylpyrimidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomethylpyrimidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphomethylpyrimidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thiamine salvage IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
NP_416606.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2183716..2184516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416606.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416606.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7LAF8, F4V3N8
    Conserved Domains (1) summary
    PRK06427
    Location:1 → 266
    PRK06427; bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
Nucleotide Protein
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