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cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946517, updated on 4-Apr-2024

Summary

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Gene symbol
cobT
Gene description
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Primary source
ASAP:ABE-0006611
Locus tag
b1991
See related
ECOCYC:EG12151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1986
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobT encodes a predicted dimethylbenzimidazole phosphoribosyltransferase. [More information is available at EcoCyc: EG12151].
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Genomic context

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Sequence:
NC_000913.3 (2063388..2064467, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene L,D-transpeptidase LdtA Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
  2. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
  3. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
NP_416495.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2063388..2064467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416495.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416495.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L9HVU9
    Conserved Domains (1) summary
    PRK00105
    Location:14 → 348
    cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Reviewed
Nucleotide Protein
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