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dacD D-alanyl-D-alanine carboxypeptidase DacD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946518, updated on 4-Apr-2024

Summary

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Gene symbol
dacD
Gene description
D-alanyl-D-alanine carboxypeptidase DacD
Primary source
ASAP:ABE-0006680
Locus tag
b2010
See related
ECOCYC:EG11893
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2004; phsE; yeeC
Summary
First 21 aa predicted to be a type I signal peptide. [More information is available at EcoGene: EG11893]. DacD, also called penicillin-binding protein 6b (PBP6b), is a D-alanyl-D-alanine carboxypeptidase and penicillin-binding protein with sequence similarity to DacA (PBP5) and DacC (PBP6) . [More information is available at EcoCyc: EG11893].
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Genomic context

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Sequence:
NC_000913.3 (2081381..2082547, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YeeA Neighboring gene DNA gyrase inhibitor Neighboring gene exodeoxyribonuclease I Neighboring gene putative thiosulfate sulfurtransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli. Peters K, et al. mBio, 2016 Jun 21. PMID 27329754, Free PMC Article
  2. Moderate deacylation efficiency of DacD explains its ability to partially restore beta-lactam resistance in Escherichia coli PBP5 mutant. Chowdhury C, et al. FEMS Microbiol Lett, 2012 Dec. PMID 22978571
  3. Sequences near the active site in chimeric penicillin binding proteins 5 and 6 affect uniform morphology of Escherichia coli. Ghosh AS, et al. J Bacteriol, 2003 Apr. PMID 12644487, Free PMC Article
  4. Physiological functions of D-alanine carboxypeptidases in Escherichia coli. Ghosh AS, et al. Trends Microbiol, 2008 Jul. PMID 18539032
  5. Endopeptidase penicillin-binding proteins 4 and 7 play auxiliary roles in determining uniform morphology of Escherichia coli. Meberg BM, et al. J Bacteriol, 2004 Dec. PMID 15576782, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables beta-lactamase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables penicillin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type D-Ala-D-Ala carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type D-Ala-D-Ala carboxypeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-alanyl-D-alanine carboxypeptidase DacD
NP_416514.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2081381..2082547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416514.4 D-alanyl-D-alanine carboxypeptidase DacD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416514.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N0IQT3
    Conserved Domains (1) summary
    PRK11397
    Location:1 → 388
    dacD; serine-type D-Ala-D-Ala carboxypeptidase DacD
Nucleotide Protein
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