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cobU cobinamide-P guanylyltransferase/cobinamide kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946519, updated on 2-May-2024

Summary

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Gene symbol
cobU
Gene description
cobinamide-P guanylyltransferase/cobinamide kinase
Primary source
ASAP:ABE-0006616
Locus tag
b1993
See related
ECOCYC:EG13238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1988
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobU encodes a predicted bifunctional protein complex with cobinamide kinase and cobinamide-P guanylyltransferase activity . [More information is available at EcoCyc: EG13238].
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Genomic context

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Sequence:
NC_000913.3 (2065219..2065764, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtA Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
  2. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
  3. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
  4. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosylcobinamide kinase (ATP-specific) activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosylcobinamide kinase (GTP-specific) activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosylcobinamide kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cobinamide kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cobinamide phosphate guanylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables cobinamide phosphate guanylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cobinamide-P guanylyltransferase/cobinamide kinase
NP_416497.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2065219..2065764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416497.1 cobinamide-P guanylyltransferase/cobinamide kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416497.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2Y0YVM8, A0A3P5DQ98
    Conserved Domains (1) summary
    PRK05800
    Location:1 → 181
    cobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Validated
Nucleotide Protein
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