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gnd 6-phosphogluconate dehydrogenase, decarboxylating [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946554, updated on 23-Nov-2023

Summary

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Gene symbol
gnd
Gene description
6-phosphogluconate dehydrogenase, decarboxylating
Primary source
ASAP:ABE-0006737
Locus tag
b2029
See related
ECOCYC:EG10411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2024
Summary
A null mutation in the gnd gene encoding 6-phosphogluconate dehydrogenase does not affect the growth rate significantly. [More information is available at EcoCyc: EG10411].
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Genomic context

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Sequence:
NC_000913.3 (2099862..2101268, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen co-polymerase Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator Neighboring gene putative glycosyltransferase WbbK Neighboring gene putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner. Sandoval JM, et al. Microbiol Res, 2015 Aug. PMID 26211962
  2. Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism. Chen YY, et al. J Struct Biol, 2010 Jan. PMID 19686854
  3. Analysis of metabolic and physiological responses to gnd knockout in Escherichia coli by using C-13 tracer experiment and enzyme activity measurement. Jiao Z, et al. FEMS Microbiol Lett, 2003 Mar 28. PMID 12670695
  4. Determination of the growth rate-regulated steps in expression of the Escherichia coli K-12 gnd gene. Pease AJ, et al. J Bacteriol, 1994 Jan. PMID 8282686, Free PMC Article
  5. Inhibition of translation initiation on Escherichia coli gnd mRNA by formation of a long-range secondary structure involving the ribosome binding site and the internal complementary sequence. Chang JT, et al. J Bacteriol, 1995 Nov. PMID 7592434, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The enzyme responsible for the TeO3(2-) toxicant reduction was identified as 6-phosphogluconate dehydrogenase (Gnd).
    Title: Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphogluconate dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphogluconate dehydrogenase (decarboxylating) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-gluconate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-gluconate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-gluconate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
6-phosphogluconate dehydrogenase, decarboxylating
NP_416533.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2099862..2101268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416533.1 6-phosphogluconate dehydrogenase, decarboxylating [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416533.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EM28
    Conserved Domains (1) summary
    PRK09287
    Location:14 → 468
    PRK09287; NADP-dependent phosphogluconate dehydrogenase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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