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gmd GDP-mannose 4,6-dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946562, updated on 23-Nov-2023

Summary

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Gene symbol
gmd
Gene description
GDP-mannose 4,6-dehydratase
Primary source
ASAP:ABE-0006803
Locus tag
b2053
See related
ECOCYC:EG11787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2047; yefA; yefN
Summary
HT_Cmplx41_Mem: [More information is available at EcoGene: EG11787].
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Genomic context

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Sequence:
NC_000913.3 (2127193..2128314, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-mannose mannosyl hydrolase Neighboring gene GDP-L-fucose synthase Neighboring gene colanic acid biosynthesis acetyltransferase WcaF Neighboring gene GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. THE BIOSYNTHESIS OF CELL WALL LIPOPOLYSACCHARIDE IN ESCHERICHIA COLI. II. GUANOSINE DIPHOSPHATE 4-KETO-6-DEOXY-D-MANNOSE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF GUANOSINE DIPHOSPHATE COLITOSE. ELBEIN AD, et al. J Biol Chem, 1965 May. PMID 14299611
  2. Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose. Somoza JR, et al. Structure, 2000 Feb 15. PMID 10673432
  3. Expression, purification and characterization of GDP-D-mannose 4,6-dehydratase from Escherichia coli. Sturla L, et al. FEBS Lett, 1997 Jul 21. PMID 9257704
  4. Evidence for effect of random genetic drift on G+C content after lateral transfer of fucose pathway genes to Escherichia coli K-12. Aoyama K, et al. Mol Biol Evol, 1994 Nov. PMID 7815923
  5. Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Struve C, et al. Microbiology (Reading), 2003 Jan. PMID 12576590

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GDP-mannose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-mannose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in colanic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GDP-mannose 4,6-dehydratase
NP_416557.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2127193..2128314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416557.1 GDP-mannose 4,6-dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416557.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7HZS7
    Conserved Domains (1) summary
    COG1089
    Location:1 → 357
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version

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