rutG pyrimidine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: rutG
Gene description: pyrimidine:H(+) symporter
Primary source: ASAP:ABE-0003401
Locus tag: b1006
See related: ECOCYC:G6517
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0997; ycdG
Summary: NtrC regulon. [More information is available at EcoGene: EG13853]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6517].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

RutG is a high-affinity permease for uracil, thymine and, at low efficiency, xanthine and recognizes also 5-fluorouracil and oxypurinol.
Title: Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.

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Function	Evidence Code	Pubs
enables nucleobase transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables pyrimidine nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine nucleotide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables uracil transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables uracil:monoatomic cation symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within pyrimidine nucleobase transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uracil catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uracil import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within uracil import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain