dcd dCTP deaminase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: dcd
Gene description: dCTP deaminase
Primary source: ASAP:ABE-0006835
Locus tag: b2065
See related: ECOCYC:EG11418
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: dus; ECK2059; paxA
Summary: This enzyme catalyzes the deamination of dCTP to dUTP in the main pathway for dTTP biosynthesis in Escherichia coli and Salmonella enterica serovar Typhimurium. [More information is available at EcoCyc: EG11418].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The crystal structure of E138D in complex with dUTP showed a hydrogen bonding network in the active site similar to wild-type enzyme.
Title: Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase.
N-terminus verified by Edman degradation on complete protein
Title: dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations.
The dCTP deaminase resembles a simple concerted system subjected to effector binding, but without the use of an allosteric site.
Title: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme.
Structures of dCTP deaminase from Escherichia coli with bound substrate and product
Title: Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables dCTP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dCTP deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables dCTP deaminase activity	IEA Inferred from Electronic Annotation more info
enables dCTP deaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dTTP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dUMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dUTP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dUTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing small molecule interconversion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleobase-containing small molecule interconversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein homotrimerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

NP_416569.1

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