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psuK putative pseudouridine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946664, updated on 2-May-2024

Summary

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Gene symbol
psuK
Gene description
putative pseudouridine kinase
Primary source
ASAP:ABE-0007168
Locus tag
b2166
See related
ECOCYC:EG11646
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2159; pscK; yeiC
Summary
PsuK was characterized as the pseudouridine kinase required for pseudouridine utilization in Escherichia coli UT189 (Preumont, 2008; Solomon, 1971). [More information is available at EcoGene: EG11646]. YeiC from the uropathogenic Escherichia coli UTI89 is a pseudouridine kinase; yeiC is the most highly induced gene when UTI89 is grown on human urine . [More information is available at EcoCyc: EG11646].
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Genomic context

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Sequence:
NC_000913.3 (2258355..2259296, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator YeiL Neighboring gene putative pseudouridine transporter Neighboring gene pseudouridine-5'-phosphate glycosidase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruA Neighboring gene 1-phosphofructokinase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI. Kim SH, et al. J Biol Chem, 2022 May. PMID 35346685, Free PMC Article
  2. Pseudouridine kinase of escherichia coli: a new enzyme. Solomon LR, et al. Biochem Biophys Res Commun, 1971 Jul 16. PMID 4334133
  3. Pseudouridulate synthetase of Escherichia coli: correlation of its activity with utilization of pseudouridine for growth. Breitman TR. J Bacteriol, 1970 Jul. PMID 4912525, Free PMC Article
  4. Growth of pyrimidineless strains of Escherichia coli on 5-ribosyluracil (pseudouridine). Breitman TR, et al. J Bacteriol, 1968 Nov. PMID 4882030, Free PMC Article
  5. The biosynthesis of pseudouridine in ribonucleic acids of Escherichia coli. Ginsberg T, et al. J Biol Chem, 1968 Dec 10. PMID 4881361

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI.
    Title: Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pseudouridine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pseudouridine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
putative pseudouridine kinase
NP_416671.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2258355..2259296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416671.1 putative pseudouridine kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416671.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3R0MTC6, A0A8S7F7W3, A0A8S7X704
    Conserved Domains (1) summary
    PRK09850
    Location:1 → 313
    PRK09850; pseudouridine kinase; Provisional
Nucleotide Protein
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