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ccmD cytochrome c maturation protein D [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946709, updated on 4-Apr-2024

Summary

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Gene symbol
ccmD
Gene description
cytochrome c maturation protein D
Primary source
ASAP:ABE-0007273
Locus tag
b2198
See related
ECOCYC:EG12169
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2190; yojM
Summary
CcmD stabilizes CcmE in the membrane. [More information is available at EcoGene: EG12169]. CcmD is an integral membrane protein that stabilizes the interaction between CcmC and CcmE for transfer of heme between the two proteins . [More information is available at EcoCyc: EG12169].
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Genomic context

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Sequence:
NC_000913.3 (2295377..2295586, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene holocytochrome c synthase CcmH component Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing heme delivery processes in cytochrome c biogenesis System I. Mavridou DA, et al. Biochemistry, 2013 Oct 15. PMID 24044352, Free PMC Article
  2. CcmD is involved in complex formation between CcmC and the heme chaperone CcmE during cytochrome c maturation. Ahuja U, et al. J Biol Chem, 2005 Jan 7. PMID 15513913
  3. Recombinant cytochromes c biogenesis systems I and II and analysis of haem delivery pathways in Escherichia coli. Feissner RE, et al. Mol Microbiol, 2006 May. PMID 16629661
  4. Extracytoplasmic prosthetic group ligation to apoproteins: maturation of c-type cytochromes. Turkarslan S, et al. Mol Microbiol, 2006 May. PMID 16629658
  5. Haem-polypeptide interactions during cytochrome c maturation. Thöny-Meyer L. Biochim Biophys Acta, 2000 Aug 15. PMID 11004446

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a function for CcmD in protein-protein interaction or membrane protein assembly required for the heme delivery process
    Title: CcmD is involved in complex formation between CcmC and the heme chaperone CcmE during cytochrome c maturation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytochrome c biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytochrome c biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytochrome c biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytochrome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cytochrome complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heme transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
cytochrome c maturation protein D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2295377..2295586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416702.1 cytochrome c maturation protein D [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416702.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A6Z5
    Conserved Domains (1) summary
    COG3114
    Location:3 → 69
    CcmD; Heme exporter protein D [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version

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