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ompC outer membrane porin C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946716, updated on 25-Jan-2024

Summary

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Gene symbol
ompC
Gene description
outer membrane porin C
Primary source
ECOCYC:EG10670
Locus tag
b2215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2207; meoA; par
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10670]. OmpC is a member of the GMP family. [More information is available at EcoCyc: EG10670].
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Genomic context

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Sequence:
NC_000913.3 (2311646..2312749, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA oxidative demethylase Neighboring gene DNA-binding transcriptional dual regulator/DNA repair protein Ada Neighboring gene FAD:protein FMN transferase Neighboring gene ncRNA Neighboring gene RcsD phosphotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of side tail fibers during the infection cycle of phage lambda. Guan J, et al. Virology, 2019 Jan 15. PMID 30463036, Free PMC Article
  2. The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap. Tran QT, et al. Proteins, 2013 Feb. PMID 23011778
  3. Disrupted OmpC causes osmosis sensitivity of Escherichia coli in alkaline medium. Wang Y, et al. J Genet Genomics, 2007 Dec. PMID 18155626
  4. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Baslé A, et al. J Mol Biol, 2006 Oct 6. PMID 16949612
  5. Functional assay of Salmonella typhi OmpC using reconstituted large unilamellar vesicles: a general method for characterization of outer membrane proteins. Sundara Baalaji N, et al. Biochimie, 2006 Oct. PMID 16765505

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
    Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
  2. findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
    Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
  3. Klebsiella pneumoniae OmpK35 and OmpK36 produced larger more permeable channels than their Escherichia coli homologs OmpF and OmpC.
    Title: Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC.
  4. established that OmpC is an additional component of the Mla system; the OmpC-MlaA complex may function to remove phospholipids directly from the outer leaflet to maintain outer membrane lipid asymmetry;work reveals a novel function for the general diffusion channel OmpC in lipid transport
    Title: Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli.
  5. Studied the rate of entry (association) and exit (dissociation) of six antibiotics to/from reconstituted E. coli porin OmpC. WaterMap was used to estimate the total water transfer energies resulting from transient occupation by each antibiotic.
    Title: The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap.
  6. N-terminus verified by Edman degradation on mature peptide
    Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
  7. OmpF or OmpC can function in the translocon complex of the colicin E2 R-domain and its BtuB receptor
    Title: Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon.
  8. for the classical porins OmpF and OmpC, our results show that the Cpx envelope stress response system plays a role in regulating their expression
    Title: The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  9. X ray structure of OmpC complexed with lactoferrin
    Title: High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin.
  10. OmpR allows distinct stepwise regulation of ompF and ompC transcription, which minimizes their overlapping expression upon changes in the medium osmolarity to achieve the reciprocal expression of ompF and ompC
    Title: Transcription regulation of ompF and ompC by a single transcription factor, OmpR.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated virion attachment to host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  
part_of pore complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
outer membrane porin C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2311646..2312749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416719.1 outer membrane porin C [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416719.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7IK29, C6K7N0, C6K7N1, C6K7N3, K7DXB2
    Conserved Domains (1) summary
    PRK10554
    Location:14 → 367
    PRK10554; outer membrane porin protein C; Provisional
Nucleotide Protein
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