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menB 1,4-dihydroxy-2-naphthoyl-CoA synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946747, updated on 4-Apr-2024

Summary

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Gene symbol
menB
Gene description
1,4-dihydroxy-2-naphthoyl-CoA synthase
Primary source
ASAP:ABE-0007476
Locus tag
b2262
See related
ECOCYC:EG11368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2256
Summary
Naphthoate-CoA synthase catalyzes a major step in menaquinone biosynthesis, formation of the bicyclic ring system . [More information is available at EcoCyc: EG11368].
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Genomic context

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Sequence:
NC_000913.3 (2375962..2376819, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Neighboring gene isochorismate synthase MenF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Li HJ, et al. Biochemistry, 2011 Nov 8. PMID 21830810, Free PMC Article
  2. A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli. Jiang M, et al. J Biol Chem, 2010 Sep 24. PMID 20643650, Free PMC Article
  3. Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis. Heide L, et al. J Biol Chem, 1982 Jul 10. PMID 7045104
  4. Biosynthesis of o-succinylbenzoic acid in a men- Escherichia coli mutant requires decarboxylation of L-glutamate at the C-1 position. Meganathan R, et al. Biochemistry, 1981 Sep 1. PMID 6117313
  5. Biosynthesis of bacterial menaquinones. Menaquinone mutants of Escherichia coli. Young IG. Biochemistry, 1975 Jan 28. PMID 1091286

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1,4-dihydroxy-2-naphthoyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables bicarbonate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in menaquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in menaquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within menaquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1,4-dihydroxy-2-naphthoyl-CoA synthase
NP_416765.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2375962..2376819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416765.1 1,4-dihydroxy-2-naphthoyl-CoA synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416765.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7KCU4
    Conserved Domains (1) summary
    PRK07396
    Location:10 → 285
    PRK07396; dihydroxynaphthoic acid synthetase; Validated
Nucleotide Protein
Heading Accession and Version

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