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nuoH NADH:quinone oxidoreductase subunit H [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946761, updated on 11-Apr-2024

Summary

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Gene symbol
nuoH
Gene description
NADH:quinone oxidoreductase subunit H
Primary source
ASAP:ABE-0007541
Locus tag
b2282
See related
ECOCYC:EG12088
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2276
Summary
NuoH is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG12088].
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Genomic context

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Sequence:
NC_000913.3 (2396465..2397442, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit K Neighboring gene NADH:quinone oxidoreductase subunit J Neighboring gene NADH:quinone oxidoreductase subunit I Neighboring gene NADH:quinone oxidoreductase subunit G Neighboring gene NADH:quinone oxidoreductase subunit F Neighboring gene NADH:quinone oxidoreductase subunit E Neighboring gene NADH:quinone oxidoreductase subunit CD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NuoH. Maliniemi P, et al. Mitochondrion, 2009 Nov. PMID 19616643
  2. Critical roles of subunit NuoH (ND1) in the assembly of peripheral subunits with the membrane domain of Escherichia coli NDH-1. Sinha PK, et al. J Biol Chem, 2009 Apr 10. PMID 19189973, Free PMC Article
  3. LHON/MELAS overlap mutation in ND1 subunit of mitochondrial complex I affects ubiquinone binding as revealed by modeling in Escherichia coli NDH-1. Pätsi J, et al. Biochim Biophys Acta, 2012 Feb. PMID 22079202
  4. Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurements. Kabir MM, et al. Appl Microbiol Biotechnol, 2004 Jul. PMID 15221231
  5. High affinity cation-binding sites in Complex I from Escherichia coli. Euro L, et al. Biochim Biophys Acta, 2009 Aug. PMID 19261245

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The kinetic effects of the NuoH-E36Q mutation suggest its proximity to the putative ubiquinone binding domain in 49kD/PSST subunits.
    Title: LHON/MELAS overlap mutation in ND1 subunit of mitochondrial complex I affects ubiquinone binding as revealed by modeling in Escherichia coli NDH-1.
  2. The results show that the fourth matrix-side loop in NuoH is probably not directly involved in ubiquinone binding or proton pumping but has a role in modifying enzyme activity.
    Title: Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NuoH.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of respiratory chain complex I NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
NADH:quinone oxidoreductase subunit H
NP_416785.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2396465..2397442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416785.1 NADH:quinone oxidoreductase subunit H [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416785.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9A7M6
    Conserved Domains (1) summary
    PRK06076
    Location:1 → 319
    PRK06076; NADH-quinone oxidoreductase subunit NuoH
Nucleotide Protein
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