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nuoA NADH:quinone oxidoreductase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946764, updated on 11-Apr-2024

Summary

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Gene symbol
nuoA
Gene description
NADH:quinone oxidoreductase subunit A
Primary source
ASAP:ABE-0007553
Locus tag
b2288
See related
ECOCYC:EG12082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2282
Summary
NuoA is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG12082].
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Genomic context

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Sequence:
NC_000913.3 (2404629..2405072, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit CD Neighboring gene NADH:quinone oxidoreductase subunit B Neighboring gene DNA-binding transcriptional dual regulator LrhA Neighboring gene glutamate--pyruvate aminotransferase AlaA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Revised transmembrane orientation of the NADH:quinone oxidoreductase subunit NuoA. Virzintiene E, et al. FEBS Lett, 2011 Oct 20. PMID 21925501
  2. Monitoring redox-dependent contribution of lipids in Fourier transform infrared difference spectra of complex I from Escherichia coli. Hielscher R, et al. Biopolymers, 2006 Jul. PMID 16358245
  3. Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. Kao MC, et al. J Biol Chem, 2004 Jul 30. PMID 15175326
  4. A role for native lipids in the stabilization and two-dimensional crystallization of the Escherichia coli NADH-ubiquinone oxidoreductase (complex I). Sazanov LA, et al. J Biol Chem, 2003 May 23. PMID 12637579
  5. Effects of the deletion of the Escherichia coli frataxin homologue CyaY on the respiratory NADH:ubiquinone oxidoreductase. Pohl T, et al. BMC Biochem, 2007 Jul 24. PMID 17650323, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in respiratory electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plasma membrane respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of respiratory chain complex I NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
NADH:quinone oxidoreductase subunit A
NP_416791.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2404629..2405072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416791.3 NADH:quinone oxidoreductase subunit A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416791.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X095, A0A8S7JM68, A0A8S7L8I1
    Conserved Domains (1) summary
    PRK06602
    Location:6 → 126
    PRK06602; NADH:ubiquinone oxidoreductase subunit A; Validated
Nucleotide Protein
Heading Accession and Version

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