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alaA glutamate--pyruvate aminotransferase AlaA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946772, updated on 2-May-2024

Summary

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Gene symbol
alaA
Gene description
glutamate--pyruvate aminotransferase AlaA
Primary source
ASAP:ABE-0007560
Locus tag
b2290
See related
ECOCYC:G7184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2284; yfbQ
Summary
AFMB Structural Genomics target Number 1 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG14101].
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Genomic context

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Sequence:
NC_000913.3 (2407561..2408778)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit A Neighboring gene DNA-binding transcriptional dual regulator LrhA Neighboring gene dCMP phosphohydrolase Neighboring gene putative transporter YfbS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli. Peña-Soler E, et al. PLoS One, 2014. PMID 25014014, Free PMC Article
  2. Cloning of genes that suppress an Escherichia coli K-12 alanine auxotroph when present in multicopy plasmids. Wang MD, et al. J Bacteriol, 1987 Dec. PMID 2890623, Free PMC Article
  3. Escherichia coli genes that reduce the lethal effects of stress. Han X, et al. BMC Microbiol, 2010 Feb 4. PMID 20128927, Free PMC Article
  4. Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli. Kim SH, et al. J Bacteriol, 2010 Oct. PMID 20729367, Free PMC Article
  5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
    Title: Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-alanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-alanine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within alanine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate--pyruvate aminotransferase AlaA
NP_416793.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2407561..2408778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416793.1 glutamate--pyruvate aminotransferase AlaA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416793.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FQ26
    Conserved Domains (1) summary
    PRK09265
    Location:1 → 404
    PRK09265; aminotransferase AlaT; Validated
Nucleotide Protein
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