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ackA acetate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946775, updated on 2-May-2024

Summary

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Gene symbol
ackA
Gene description
acetate kinase
Primary source
ASAP:ABE-0007579
Locus tag
b2296
See related
ECOCYC:EG10027
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2290
Summary
N-terminus is blocked (Fox, 86). [More information is available at EcoGene: EG10027]. Regulation has been described . [More information is available at EcoCyc: EG10027].
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Genomic context

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Sequence:
NC_000913.3 (2413470..2414672)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF03887 family protein YfbU Neighboring gene PF04217 family membrane protein YfbV Neighboring gene phosphate acetyltransferase Neighboring gene putative transporter YfcC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enzymatic phosphorylation of acetate. ROSE IA, et al. J Biol Chem, 1954 Dec. PMID 13221579
  2. Evidence that acetyl phosphate functions as a global signal during biofilm development. Wolfe AJ, et al. Mol Microbiol, 2003 May. PMID 12753190
  3. Regulation of acetyl phosphate synthesis and degradation, and the control of flagellar expression in Escherichia coli. Prüss BM, et al. Mol Microbiol, 1994 Jun. PMID 7934904
  4. Evidence for an essential arginine residue at the active site of Escherichia coli acetate kinase. Wong SS, et al. Biochim Biophys Acta, 1981 Jul 24. PMID 6268170
  5. Structure of the metal-nucleotide complex in the acetate kinase reaction. A study with gamma-32P-labeled phosphorothioate analogs of ATP. Romaniuk PJ, et al. J Biol Chem, 1981 Jul 25. PMID 6265443

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acetate and glucose fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
    Title: Acetate fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
  2. Deletion of the E. coli ackA gene (together with deletions of other ferementation disruption genes) increased production of succinate
    Title: Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C.
  3. pta/ackA recF mutants are viable, suggesting, together with the inviability of pta/ackA recBC mutants, that chromosomal lesions due to the pta/ackA defect are of the double-strand-break type.
    Title: A defect in the acetyl coenzyme A<-->acetate pathway poisons recombinational repair-deficient mutants of Escherichia coli.
  4. essential for anaerobic growth of E. coli on xylose due to energetic constraints
    Title: Pyruvate formate lyase and acetate kinase are essential for anaerobic growth of Escherichia coli on xylose.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, carboxyl group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acetate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in acetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within propionate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
acetate kinase
NP_416799.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2413470..2414672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416799.1 acetate kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416799.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6L7CFM8
    Conserved Domains (1) summary
    PRK00180
    Location:4 → 399
    PRK00180; acetate kinase A/propionate kinase 2; Reviewed
Nucleotide Protein
Heading Accession and Version

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