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fabB 3-oxoacyl-[acyl carrier protein] synthase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946799, updated on 11-Apr-2024

Summary

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Gene symbol
fabB
Gene description
3-oxoacyl-[acyl carrier protein] synthase 1
Primary source
ASAP:ABE-0007675
Locus tag
b2323
See related
ECOCYC:EG10274
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2317; fabC
Summary
There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG10274].
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Genomic context

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Sequence:
NC_000913.3 (2440385..2441605, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene erythronate-4-phosphate dehydrogenase Neighboring gene putative flagella assembly protein Neighboring gene putative transporter YfcJ Neighboring gene fused tRNA 5-aminomethyl-2-thiouridylate methyltransferase and tRNA 5-aminomethyl-2-thiouridylate synthase Neighboring gene PF08891 family protein YfcL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of colonization-defective Escherichia coli mutants reveals critical requirement for fatty acids in bacterial colony formation. Nosho K, et al. Microbiology (Reading), 2018 Sep. PMID 29906256, Free PMC Article
  2. Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis. Pappenberger G, et al. Acta Crystallogr D Biol Crystallogr, 2007 Dec. PMID 18084068, Free PMC Article
  3. A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Jackowski S, et al. Antimicrob Agents Chemother, 2002 May. PMID 11959552, Free PMC Article
  4. beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket. McGuire KA, et al. Biochemistry, 2001 Aug 21. PMID 11502177
  5. Structures of beta-ketoacyl-acyl carrier protein synthase I complexed with fatty acids elucidate its catalytic machinery. Olsen JG, et al. Structure, 2001 Mar 7. PMID 11286890

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data taken together support a gating mechanism that regulates acyl-ACP binding and substrate delivery to the beta-ketoacyl-acyl carrier protein (ACP) synthases (FabF and FabB) active site.
    Title: Gating mechanism of elongating β-ketoacyl-ACP synthases.
  2. The authors isolated Escherichia coli mutants that had decreased frequencies of colony formation but could grow in liquid medium from a temperature-sensitive mutant collection. Mutations were identified in fabB, which is essential for the synthesis of long unsaturated fatty acids.
    Title: Isolation of colonization-defective Escherichia coli mutants reveals critical requirement for fatty acids in bacterial colony formation.
  3. the key reaction in UFA synthesis catalyzed by FabB is elongation of the cis-3-decenoyl-ACP produced by FabA.
    Title: Escherichia coli unsaturated fatty acid synthesis: complex transcription of the fabA gene and in vivo identification of the essential reaction catalyzed by FabB.
  4. N-terminus verified by Edman degradation on complete protein
    Title: beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-oxoacyl-[acyl carrier protein] synthase 1
NP_416826.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2440385..2441605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416826.1 3-oxoacyl-[acyl carrier protein] synthase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416826.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AH73, A0A6C9QG34, A0A7A7F5U5
    Conserved Domains (1) summary
    PRK07967
    Location:1 → 405
    PRK07967; beta-ketoacyl-ACP synthase I
Nucleotide Protein
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