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fadL long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946820, updated on 2-May-2024

Summary

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Gene symbol
fadL
Gene description
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor
Primary source
ASAP:ABE-0007740
Locus tag
b2344
See related
ECOCYC:EG10280
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2338; ttr
Summary
FadL is an outer membrane protein involved with the uptake of long-chain fatty acids . [More information is available at EcoCyc: EG10280].
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Genomic context

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Sequence:
NC_000913.3 (2461306..2462646)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene protein YfdF Neighboring gene intermembrane phospholipid transport system - outer membrane lipoprotein MlaA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C-terminal tails of the bacterial chaperonin GroEL stimulate protein folding by directly altering the conformation of a substrate protein. Weaver J, et al. J Biol Chem, 2014 Aug 15. PMID 24970895, Free PMC Article
  2. Ligand-gated diffusion across the bacterial outer membrane. Lepore BW, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21593406, Free PMC Article
  3. Transmembrane passage of hydrophobic compounds through a protein channel wall. Hearn EM, et al. Nature, 2009 Mar 19. PMID 19182779, Free PMC Article
  4. Dynamic mechanism of fatty acid transport across cellular membranes through FadL: molecular dynamics simulations. Zou H, et al. J Phys Chem B, 2008 Oct 16. PMID 18811191
  5. The FadL family: unusual transporters for unusual substrates. van den Berg B. Curr Opin Struct Biol, 2005 Aug. PMID 16005205

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
    Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
  2. Data show that high-affinity (submicromolar) substrate binding to the outer membrane long-chain fatty acid transporter FadL from Escherichia coli causes conformational changes in the N terminus that open up a channel for substrate diffusion.
    Title: Ligand-gated diffusion across the bacterial outer membrane.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid transporting porin activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transporting porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2461306..2462646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416846.2 long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416846.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3J2W2, A0A1X3JER8, A0A979H2N4, B7LBJ8, B7N5V5, D3H227, D6JCN9, E1J986, E6BKU4, F4T0R5, F4VEB0
    Conserved Domains (1) summary
    PRK10716
    Location:1 → 446
    PRK10716; long-chain fatty acid transporter FadL
Nucleotide Protein
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