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glk glucokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946858, updated on 2-May-2024

Summary

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Gene symbol
glk
Gene description
glucokinase
Primary source
ASAP:ABE-0007875
Locus tag
b2388
See related
ECOCYC:EG12957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2384
Summary
The cytoplasmic glucokinase is not required for growth on glucose as the carbon source, because glucose is phosphorylated during transport by the PTS system. [More information is available at EcoCyc: EG12957].
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Genomic context

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Sequence:
NC_000913.3 (2508461..2509426, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme IIC component FryC Neighboring gene putative PTS enzyme IIB component FryB Neighboring gene putative transport protein YfeO Neighboring gene DUF2502 domain-containing protein YpeC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mutability of enzyme active-site shape determinants. Miller BG. Protein Sci, 2007 Sep. PMID 17766388, Free PMC Article
  2. Hypothesis: structures, evolution, and ancestor of glucose kinases in the hexokinase family. Kawai S, et al. J Biosci Bioeng, 2005 Apr. PMID 16233797
  3. Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose. Lunin VV, et al. J Bacteriol, 2004 Oct. PMID 15466045, Free PMC Article
  4. THE UTILIZATION OF GLUCOSE 6-PHOSPHATE BY GLUCOKINASELESS AND WILD-TYPE STRAINS OF ESCHERICHIA COLI. FRAENKEL DG, et al. Proc Natl Acad Sci U S A, 1964 Nov. PMID 14231443, Free PMC Article
  5. PREFERENTIAL GALACTOSE UTILIZATION IN A MUTANT STRAIN OF E. COLI. ASENSIO C, et al. Arch Biochem Biophys, 1963 Dec. PMID 14103281

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucokinase
NP_416889.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2508461..2509426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416889.1 glucokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416889.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L5V6Q0, F4V4D5
    Conserved Domains (1) summary
    PRK00292
    Location:2 → 316
    glk; glucokinase; Provisional
Nucleotide Protein
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