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cysK cysteine synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946877, updated on 4-Feb-2024

Summary

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Gene symbol
cysK
Gene description
cysteine synthase A
Primary source
ASAP:ABE-0007957
Locus tag
b2414
See related
ECOCYC:EG10192
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2409; ssi5
Summary
CysK forms a bienzyme complex with CysE. [More information is available at EcoGene: EG10192]. Cysteine synthase A carries out the second step in the pathway of cysteine biosynthesis, converting O-acetyl-serine into L-cysteine. [More information is available at EcoCyc: EG10192].
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Genomic context

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Sequence:
NC_000913.3 (2532409..2533380)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZipA Neighboring gene sulfate:H(+) symporter Neighboring gene phosphocarrier protein HPr Neighboring gene PTS enzyme I

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Induction of the Escherichia coli cysK gene by genetic and environmental factors. Yamamoto K, et al. FEMS Microbiol Lett, 2011 Oct. PMID 22092684
  2. Location on the Escherichia coli genome of a gene specifying O-acetylserine (thiol)-lyase. Boronat A, et al. J Gen Microbiol, 1984 Mar. PMID 6374031
  3. Properties of cysK mutants of Escherichia coli K12. Wiater A, et al. Acta Biochim Pol, 1979. PMID 388955
  4. Isolation and characterization of cysK mutants of Escherichia coli K12. Fimmel AL, et al. J Gen Microbiol, 1977 Nov. PMID 338862
  5. Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex. Benoni R, et al. FEBS Lett, 2017 May. PMID 28337759, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that bacterial serine acetyltransferase (CysE) is activated when bound to O-acetylserine sulfhydrylase-A sulfhydrylase (CysK).
    Title: Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex.
  2. The authors showed that the expression of cysK is regulated by several genetic and environmental factors in addition to CysB: two genetic factors, OmpR and CysE, and lithium.
    Title: Induction of the Escherichia coli cysK gene by genetic and environmental factors.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-cysteine desulfhydrase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-cysteine desulfhydrase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables S-carboxymethylcysteine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteine biosynthetic process from serine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cysteine biosynthetic process from serine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cysteine synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cysteine synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cysteine synthase A
NP_416909.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2532409..2533380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416909.1 cysteine synthase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416909.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6L7C9E2
    Conserved Domains (1) summary
    TIGR01139
    Location:8 → 312
    cysK; cysteine synthase A
Nucleotide Protein
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