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fhuB iron(III) hydroxamate ABC transporter membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946890, updated on 11-Apr-2024

Summary

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Gene symbol
fhuB
Gene description
iron(III) hydroxamate ABC transporter membrane subunit
Primary source
ASAP:ABE-0000526
Locus tag
b0153
See related
ECOCYC:EG10303
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0152
Summary
fhuB mutants are albomycin resistant. [More information is available at EcoGene: EG10303]. The FhuBCD ATP-dependent iron (III) hydroxamate transporter is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10303].
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Genomic context

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Sequence:
NC_000913.3 (171462..173444)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferrichrome outer membrane transporter/phage receptor Neighboring gene iron(III) hydroxamate ABC transporter ATP binding subunit Neighboring gene iron(III) hydroxamate ABC transporter periplasmic binding protein Neighboring gene glutamate-1-semialdehyde 2,1-aminomutase Neighboring gene protein YadX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transmembrane topology of the two FhuB domains representing the hydrophobic components of bacterial ABC transporters involved in the uptake of siderophores, haem and vitamin B12. Groeger W, et al. Microbiology (Reading), 1998 Oct. PMID 9802017
  2. Genetic and biochemical characterization of the Escherichia coli K-12 fhuB mutation. Prody CA, et al. J Bacteriol, 1984 Mar. PMID 6321441, Free PMC Article
  3. Iron(III) hydroxamate transport of Escherichia coli: restoration of iron supply by coexpression of the N- and C-terminal halves of the cytoplasmic membrane protein FhuB cloned on separate plasmids. Köster W, et al. Mol Gen Genet, 1990 Sep. PMID 2270077
  4. Point mutations in two conserved glycine residues within the integral membrane protein FhuB affect iron(III) hydroxamate transport. Köster W, et al. Mol Gen Genet, 1992 Apr. PMID 1588908
  5. Conserved amino acids in the N- and C-terminal domains of integral membrane transporter FhuB define sites important for intra- and intermolecular interactions. Böhm B, et al. Mol Microbiol, 1996 Apr. PMID 8861219

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron ion import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore-dependent iron import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex TAS
Traceable Author Statement
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
iron(III) hydroxamate ABC transporter membrane subunit
NP_414695.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    171462..173444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414695.1 iron(III) hydroxamate ABC transporter membrane subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414695.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DYM9, A0A6M9WZA6
    Conserved Domains (1) summary
    PRK10577
    Location:1 → 660
    PRK10577; Fe(3+)-hydroxamate ABC transporter permease FhuB
Nucleotide Protein
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