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gltX glutamate--tRNA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946906, updated on 2-May-2024

Summary

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Gene symbol
gltX
Gene description
glutamate--tRNA ligase
Primary source
ASAP:ABE-0007911
Locus tag
b2400
See related
ECOCYC:EG10407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2394; gltM; gluRS
Summary
The zinc binding motif Cys98-x-Cys100-x(24)-Cys125-x-H127 of GltX categorizes this as a SWIM domain (standard C-x-C-x(n)-C-x-H with n=6-25). [More information is available at EcoGene: EG10407].
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Genomic context

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Sequence:
NC_000913.3 (2519257..2520672, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator YfeC Neighboring gene putative DNA-binding transcriptional regulator YfeD Neighboring gene tRNA-Val Neighboring gene tRNA-Val

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A C-truncated glutamyl-tRNA synthetase specific for tRNA(Glu) is stimulated by its free complementary distal domain: mechanistic and evolutionary implications. Dubois DY, et al. Biochemistry, 2009 Jun 30. PMID 19496540
  2. The role of the catalytic domain of E. coli GluRS in tRNAGln discrimination. Dasgupta S, et al. FEBS Lett, 2009 Jun 18. PMID 19481543
  3. Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. Bernier S, et al. J Enzyme Inhib Med Chem, 2005 Feb. PMID 15895686
  4. The zinc-binding site of a class I aminoacyl-tRNA synthetase is a SWIM domain that modulates amino acid binding via the tRNA acceptor arm. Banerjee R, et al. Eur J Biochem, 2004 Feb. PMID 14764088
  5. In vivo formation of glutamyl-tRNA(Gln) in Escherichia coli by heterologous glutamyl-tRNA synthetases. Núñez H, et al. FEBS Lett, 2004 Jan 16. PMID 14741355

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glutamyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutamate--tRNA ligase
NP_416899.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2519257..2520672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416899.1 glutamate--tRNA ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416899.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0B5HLG4, A0A8S7HVE6
    Conserved Domains (1) summary
    PRK01406
    Location:1 → 461
    gltX; glutamyl-tRNA synthetase; Reviewed
Nucleotide Protein
Heading Accession and Version

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