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maeB malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946947, updated on 2-May-2024

Summary

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Gene symbol
maeB
Gene description
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
Primary source
ASAP:ABE-0008111
Locus tag
b2463
See related
ECOCYC:G7293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2458; ypfF
Summary
Acetyl-CoA and cAMP are allosteric inhibitors. [More information is available at EcoGene: EG14193]. There are two malic enzymes in Escherichia coli, one NAD-linked (encoded by the maeA gene) and the other NADP-linked (encoded by the maeB gene) . [More information is available at EcoCyc: G7293].
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Genomic context

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Sequence:
NC_000913.3 (2576098..2578377, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ethanolamine utilization acetate kinase EutQ Neighboring gene putative ethanolamine utilization acetate kinase EutP Neighboring gene putative ethanolamine catabolic microcompartment shell protein EutS Neighboring gene transaldolase A Neighboring gene transketolase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bifunctional Malic/Malolactic Enzyme Provides a Novel Mechanism for NADPH-Balancing in Bacillus subtilis. Hörl M, et al. mBio, 2021 Apr 6. PMID 33824210, Free PMC Article
  2. Biochemical properties and physiological roles of NADP-dependent malic enzyme in Escherichia coli. Wang B, et al. J Microbiol, 2011 Oct. PMID 22068497
  3. Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide phosphate specific malic enzyme, depending on whether magnesium ion or manganese ion serves as divalent cation. Brown DA, et al. Biochemistry, 1981 Apr 28. PMID 7016178
  4. Regulatory roles of cyclic 3',5'-AMP in bacteria: control of malic enzyme of Escherichia coli. Sanwal BD, et al. Biochem Biophys Res Commun, 1969 May 22. PMID 4389228
  5. Malic enzyme of Escherichia coli. Possible mechanism for allosteric effects. Sanwal BD, et al. J Biol Chem, 1969 Apr 10. PMID 4388615

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicated that MaeB was important for NADPH production for bacterial growth on acetate.
    Title: Biochemical properties and physiological roles of NADP-dependent malic enzyme in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables malic enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables malolactic enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
NP_416958.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2576098..2578377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416958.1 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416958.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QAP0, A0AA88ES88
    Conserved Domains (1) summary
    PRK07232
    Location:3 → 756
    PRK07232; bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Nucleotide Protein
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