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purC phosphoribosylaminoimidazole-succinocarboxamide synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946957, updated on 2-May-2024

Summary

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Gene symbol
purC
Gene description
phosphoribosylaminoimidazole-succinocarboxamide synthase
Primary source
ASAP:ABE-0008156
Locus tag
b2476
See related
ECOCYC:EG10791
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ade; ade(g); ECK2472
Summary
SAICAR synthase converts 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) to 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide (SAICAR). [More information is available at EcoGene: EG10791]. Overproduction and purification of PurC . [More information is available at EcoCyc: EG10791].
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Genomic context

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Sequence:
NC_000913.3 (2596905..2597618, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA(Met) cytidine acetyltransferase Neighboring gene uncharacterized protein YpfJ Neighboring gene outer membrane protein assembly factor BamC Neighboring gene 4-hydroxy-tetrahydrodipicolinate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase. Ginder ND, et al. J Biol Chem, 2006 Jul 28. PMID 16687397
  2. Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. Nelson SW, et al. Biochemistry, 2005 Jan 18. PMID 15641804
  3. Identification of the purC gene product of Escherichia coli. Parker J. J Bacteriol, 1984 Mar. PMID 6365889, Free PMC Article
  4. Potassium/proton antiport system of Escherichia coli. Radchenko MV, et al. J Biol Chem, 2006 Jul 21. PMID 16687400
  5. DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12. Tiedeman AA, et al. J Bacteriol, 1990 Oct. PMID 2120198, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  2. analysis of nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase
    Title: Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase.
  3. In this study, a rapid equilibrium random ter-ter kinetic mechanism is established for SAICAR synthetase by initial velocity kinetics and patterns of linear inhibition by inosine monophosphate, adenosine 5'-(beta,gamma-imido)triphosphate, and maleate.
    Title: Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
phosphoribosylaminoimidazole-succinocarboxamide synthase
NP_416971.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2596905..2597618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416971.1 phosphoribosylaminoimidazole-succinocarboxamide synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416971.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H2Z1E0, A0A192C9L9, A0A1X3I3R2, A0A1X3J2I1, A0A1X3JEX7, A0A9X6EMZ6, A0AA36KZF7, F4THE6, F4V4J9, Q1R8Q1
    Conserved Domains (1) summary
    PRK09362
    Location:1 → 237
    PRK09362; phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
Nucleotide Protein
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Other Literature Sources
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Research Materials