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hyfB hydrogenase 4 component B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946961, updated on 11-Apr-2024

Summary

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Gene symbol
hyfB
Gene description
hydrogenase 4 component B
Primary source
ASAP:ABE-0008181
Locus tag
b2482
See related
ECOCYC:EG11282
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2478; yffF
Summary
On the basis of sequence similarity to hycBCDEFG, which encodes hydrogenase 3, the ten-gene cluster hyfABCDEFGHIJ was presumed to encode a hydrogenase that interacts with formate dehydrogenase (FdhF) to produce an active formate hydrogenlyase complex. [More information is available at EcoCyc: EG11282].
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Genomic context

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Sequence:
NC_000913.3 (2601818..2603836)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transcriptional regulator GcvR Neighboring gene thiol peroxidase Neighboring gene hydrogenase 4 component A Neighboring gene hydrogenase 4 component C Neighboring gene hydrogenase 4 component D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map. Andrews SC, et al. J Gen Microbiol, 1991 Feb. PMID 2016588
  2. Dissecting the roles of Escherichia coli hydrogenases in biohydrogen production. Redwood MD, et al. FEMS Microbiol Lett, 2008 Jan. PMID 17995952
  3. Transcriptional control of hydrogen production during mixed carbon fermentation by hydrogenases 4 (hyf) and 3 (hyc) in Escherichia coli. Trchounian K. Gene, 2012 Sep 10. PMID 22771922
  4. Participation of hyf-encoded hydrogenase 4 in molecular hydrogen release coupled with proton-potassium exchange in Escherichia coli. Bagramyan K, et al. Membr Cell Biol, 2001. PMID 11817571
  5. Phosphorylation of ribosomal proteins in HeLa cells infected with vaccinia virus. Kaerlein M, et al. Nature, 1976 Jan 15. PMID 1246353

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
involved_in anaerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in anaerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in formate oxidation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of [Ni-Fe] hydrogenase complex RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
part_of formate dehydrogenase complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
hydrogenase 4 component B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2601818..2603836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416977.1 hydrogenase 4 component B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416977.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QSF8
    Conserved Domains (1) summary
    PRK06521
    Location:1 → 671
    PRK06521; hydrogenase 4 subunit B; Validated
Nucleotide Protein
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