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ppx exopolyphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946970, updated on 4-Apr-2024

Summary

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Gene symbol
ppx
Gene description
exopolyphosphatase
Primary source
ASAP:ABE-0008238
Locus tag
b2502
See related
ECOCYC:EG11403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2498
Summary
PDB structure from O157:H7 has identical sequence as K-12. [More information is available at EcoGene: EG11403]. Exopolyphosphatase (PPX) degrades inorganic polyphosphates (polyP). [More information is available at EcoCyc: EG11403].
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Genomic context

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Sequence:
NC_000913.3 (2625115..2626656)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase Neighboring gene cyclic di-GMP phosphodiesterase PdeF Neighboring gene nickel/cobalt stress response protein YfgG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach. Boetsch C, et al. Arch Biochem Biophys, 2016 Sep 15. PMID 27424154
  2. ATP as effector of inorganic pyrophosphatase of Escherichia coli. The role of residue Lys112 in binding effectors. Rodina EV, et al. Biochemistry (Mosc), 2007 Jan. PMID 17309443
  3. Origin of exopolyphosphatase processivity: Fusion of an ASKHA phosphotransferase and a cyclic nucleotide phosphodiesterase homolog. Alvarado J, et al. Structure, 2006 Aug. PMID 16905100
  4. The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains. Rangarajan ES, et al. J Mol Biol, 2006 Jun 23. PMID 16678853
  5. Polyphosphate binding and chain length recognition of Escherichia coli exopolyphosphatase. Bolesch DG, et al. J Biol Chem, 2000 Oct 27. PMID 10922361

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. H(378) is a fundamental gatekeeper for the recognition of long chain polyphosphate
    Title: Putative binding mode of Escherichia coli exopolyphosphatase and polyphosphates based on a hybrid in silico/biochemical approach.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exopolyphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exopolyphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorus metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within polyphosphate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exopolyphosphatase
NP_416997.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2625115..2626656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416997.1 exopolyphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416997.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ATD1, A0A8S7F3A2, F4V4L8
    Conserved Domains (1) summary
    PRK10854
    Location:1 → 513
    PRK10854; exopolyphosphatase; Provisional
Nucleotide Protein
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