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purN phosphoribosylglycinamide formyltransferase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946973, updated on 2-May-2024

Summary

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Gene symbol
purN
Gene description
phosphoribosylglycinamide formyltransferase 1
Primary source
ASAP:ABE-0008232
Locus tag
b2500
See related
ECOCYC:EG10799
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ade; ade(c); ECK2496
Summary
Based on polarity studies, the expression of the purN gene originates from the purM control region and thus forms a purMN operon. [More information is available at EcoCyc: EG10799].
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Genomic context

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Sequence:
NC_000913.3 (2622234..2622872)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil:H(+) symporter UraA Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene polyphosphate kinase Neighboring gene exopolyphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations. Morikis D, et al. Protein Sci, 2001 Nov. PMID 11604543, Free PMC Article
  2. A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. Su Y, et al. J Mol Biol, 1998 Aug 21. PMID 9698564
  3. Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli. Inglese J, et al. Biochemistry, 1990 Jul 17. PMID 2204419
  4. Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase. Inglese J, et al. Biochemistry, 1990 Feb 13. PMID 2185839
  5. Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase. Almassy RJ, et al. Proc Natl Acad Sci U S A, 1992 Jul 1. PMID 1631098, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Active-site mapping and site-specific mutagenesis of glycinamide ribonucleotide transformylase from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylglycinamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylglycinamide formyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoribosylglycinamide formyltransferase 1
NP_416995.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2622234..2622872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416995.1 phosphoribosylglycinamide formyltransferase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416995.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AEY1, A0AA88EUE5
    Conserved Domains (1) summary
    PRK05647
    Location:1 → 199
    purN; phosphoribosylglycinamide formyltransferase; Reviewed
Nucleotide Protein
Heading Accession and Version

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