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uraA uracil:H(+) symporter UraA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946978, updated on 4-Apr-2024

Summary

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Gene symbol
uraA
Gene description
uracil:H(+) symporter UraA
Primary source
ASAP:ABE-0008219
Locus tag
b2497
See related
ECOCYC:EG12129
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2493
Summary
UraA is a probable high affinity uracil transporter, responsible for the uptake of uracil. [More information is available at EcoCyc: EG12129].
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Genomic context

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Sequence:
NC_000913.3 (2618871..2620160, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase YfgD Neighboring gene inibitor of reinitiation of DNA replication Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin. Kalli AC, et al. PLoS Comput Biol, 2015 Mar. PMID 25729859, Free PMC Article
  2. Structure and mechanism of the uracil transporter UraA. Lu F, et al. Nature, 2011 Apr 14. PMID 21423164
  3. Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli. Botou M, et al. Mol Microbiol, 2018 Apr. PMID 29437264
  4. Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters. Yu X, et al. Cell Res, 2017 Aug. PMID 28621327, Free PMC Article
  5. Regulation of upp expression in Escherichia coli by UTP-sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription. Tu AH, et al. J Bacteriol, 1997 Nov. PMID 9352914, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UraA are permeases specific for uracil and 5-fluorouracil.
    Title: Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.
  2. Used molecular dynamics simulations to study the bacterial UraA H+-uracil symporter in lipid bilayers.
    Title: Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nucleobase transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil:monoatomic cation symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil:monoatomic cation symporter activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within uracil import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uracil transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uracil:H(+) symporter UraA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2618871..2620160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416992.1 uracil:H(+) symporter UraA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416992.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA88EVJ7
    Conserved Domains (1) summary
    PRK10720
    Location:2 → 429
    PRK10720; uracil transporter; Provisional
Nucleotide Protein
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