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upp uracil phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946979, updated on 2-May-2024

Summary

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Gene symbol
upp
Gene description
uracil phosphoribosyltransferase
Primary source
ASAP:ABE-0008224
Locus tag
b2498
See related
ECOCYC:EG11332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2494; uraP
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Genomic context

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Sequence:
NC_000913.3 (2620246..2620872, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inibitor of reinitiation of DNA replication Neighboring gene uracil:H(+) symporter UraA Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A long T. A tract in the upp initially transcribed region is required for regulation of upp expression by UTP-dependent reiterative transcription in Escherichia coli. Cheng Y, et al. J Bacteriol, 2001 Jan. PMID 11114920, Free PMC Article
  2. Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity. Kawamura K, et al. Cancer Gene Ther, 2000 Apr. PMID 10811483
  3. Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli. Jensen KF, et al. Eur J Biochem, 1996 Sep 15. PMID 8856065
  4. Purification and some properties of uracil phosphoribosyltransferase from Escherichia coli K12. Rasmussen UB, et al. Biochim Biophys Acta, 1986 Apr 11. PMID 3513846
  5. Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine. Tiraby M, et al. FEMS Microbiol Lett, 1998 Oct 1. PMID 9785450

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables uracil phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine-containing compound salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in uracil salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
uracil phosphoribosyltransferase
NP_416993.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2620246..2620872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416993.2 uracil phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416993.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A775YYU0
    Conserved Domains (1) summary
    PRK00129
    Location:1 → 208
    upp; uracil phosphoribosyltransferase; Reviewed
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials