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puuC gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947003, updated on 4-Apr-2024

Summary

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Gene symbol
puuC
Gene description
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
Primary source
ASAP:ABE-0004376
Locus tag
b1300
See related
ECOCYC:EG10036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
aldH; ECK1295
Summary
PuuC is inferred to be the -glutamyl--aminobutyraldehyde dehydrogenase in a putrescine utilization pathway; together with PuuB, -glutamyl--aminobutyrate is produced from -glutamylputrescine . [More information is available at EcoCyc: EG10036].
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Genomic context

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Sequence:
NC_000913.3 (1362743..1364230)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl-gamma-aminobutyrate hydrolase Neighboring gene DNA-binding transcriptional repressor PuuR Neighboring gene gamma-glutamylputrescine oxidase Neighboring gene 4-aminobutyrate aminotransferase PuuE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate. Jo JE, et al. Appl Microbiol Biotechnol, 2008 Nov. PMID 18668238
  2. The RIB element in the goaG-pspF intergenic region of Escherichia coli. Jovanovic G, et al. J Bacteriol, 1997 May. PMID 9150200, Free PMC Article
  3. Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases. Heim R, et al. Gene, 1991 Mar 1. PMID 1840553
  4. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
  5. Transcriptional response of Escherichia coli to external copper. Yamamoto K, et al. Mol Microbiol, 2005 Apr. PMID 15773991

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AldH preferred NAD+ over NADP+ as a cofactor for the oxidation.
    Title: Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within putrescine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
NP_415816.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1362743..1364230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415816.1 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415816.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L9HZX9, A0A7H9SFV4
    Conserved Domains (1) summary
    PRK09847
    Location:1 → 494
    PRK09847; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional
Nucleotide Protein
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