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pdxJ pyridoxine 5'-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947039, updated on 23-Nov-2023

Summary

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Gene symbol
pdxJ
Gene description
pyridoxine 5'-phosphate synthase
Primary source
ASAP:ABE-0008435
Locus tag
b2564
See related
ECOCYC:EG10693
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2562
Summary
Pyridoxine 5'-phosphate synthase is one of two key enzymes involved in the ring closure of the aromatic pyridoxin ring in vitamin B12 biosynthesis. [More information is available at EcoCyc: EG10693].
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Genomic context

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Sequence:
NC_000913.3 (2700998..2701729, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene recombination mediator protein RecO Neighboring gene 30S ribosomal subunit maturation GTPase Era Neighboring gene RNase III

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multistate binding in pyridoxine 5'-phosphate synthase: 1.96 A crystal structure in complex with 1-deoxy-D-xylulose phosphate. Yeh JI, et al. Biochemistry, 2002 Oct 1. PMID 12269807
  2. Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis. Garrido-Franco M, et al. J Mol Biol, 2002 Aug 23. PMID 12206776
  3. Structural basis for the function of pyridoxine 5'-phosphate synthase. Franco MG, et al. Structure, 2001 Mar 7. PMID 11286891
  4. Crystallization and preliminary X-ray crystallographic analysis of PdxJ, the pyridoxine 5'-phosphate synthesizing enzyme. Garrido Franco M, et al. Acta Crystallogr D Biol Crystallogr, 2000 Aug. PMID 10944349
  5. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. Man TK, et al. J Bacteriol, 1996 Apr. PMID 8636054, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Locating essential Escherichia coli genes by using mini-Tn10 transposons: the pdxJ operon.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxine 5'-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxine 5'-phosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxine 5'-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring nitrogenous groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pyridoxine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pyridoxine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pyridoxine 5'-phosphate synthase
NP_417059.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2700998..2701729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417059.1 pyridoxine 5'-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417059.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NCV9
    Conserved Domains (1) summary
    PRK05265
    Location:4 → 241
    PRK05265; pyridoxine 5'-phosphate synthase; Provisional
Nucleotide Protein
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